1211565-07-9

Usage

Uses

Used in Pharmaceutical Industry:
3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(diMethylaMino)cyclohexyl]aMino]--Cyclobutene-1,2-dione is used as a synthetic intermediate for the production of pharmaceuticals and other organic compounds. Its unique chemical structure and properties make it versatile for use in various chemical reactions and synthesis processes, contributing to the development of new drugs and therapeutic agents.
Used in Chemical Research:
3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(diMethylaMino)cyclohexyl]aMino]--Cyclobutene-1,2-dione is used as a research compound in chemical research, where its properties and reactivity are studied to gain insights into the behavior of similar compounds and to develop new synthetic methods and applications.

Upstream product

• 50-00-0 formaldehyd 
• 1223105-85-8 3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione 
• 320778-92-5 (1R,2R)-N,N-dimethylcyclohexane-1,2-diamine 
• 5222-73-1 3,4-dimethoxy-3-cyclobutene-1,2-dione 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 

Relevant academic research and scientific papers

Enantioselective α-amination of 1,3-dicarbonyl compounds using squaramide derivatives as hydrogen bonding catalysts

Figure presented Catalytic enantioselective α-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were

A New Class of Squaramide-Containing Phase-Transfer Catalysts: Application to Asymmetric Fluorination of β-Keto Esters

The squaramide moiety has proven to be a powerful hydrogen-bonding donor in organocatalysis, but chiral phase-transfer catalysts bearing the squaramide motif have not been reported so far. Reported herein is this kind of catalyst and their catalytic performance in the asymmetric fluorination of β-keto esters.

ONE-POT SYNTHESIS OF SQUARAMIDES

The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time consuming purificat

Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines

Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees. The Royal Society of Chemistry 2010.