375368-83-5Relevant articles and documents
Preparation method of poly-substitution 6-fluorine picolinic acid
-
Paragraph 0021-0023; 0025-0027, (2018/09/08)
The invention discloses a preparation method of poly-substitution 6-fluorine picolinic acid. The preparation method comprises the following steps: performing diazotization on the poly-substitution 2-amino-6-picoline and a diazotized agent; performing a reaction on a fluorinating agent to generate the poly-substitution 2-amino-6-fluoride pyridine; performing an oxidizing reaction on the poly-substitution 6-picoline-2-fluoride pyridine and an oxidizing agent to obtain the poly-substitution 6-fluorine picolinic acid. The invention provides a novel initial raw material for preparing poly-substitution 6-fluorine picolinic acid, and correspondingly provides a novel reaction path and process. The poly-substitution 2-amino-6-picoline is taken as the initial raw material has the advantages of low cost and readily-available; the prepared 6-fluorine picolinic acid has the advantages of simple process, low requirement on reaction conditions, high security performance, high product yield and purityand easiness in realizing scale production.