121193-91-7

Basic information

• Product Name: 2-(Naphthalen-1-yl)pyrrolidine
• Synonyms: 2-NAPHTHALEN-1-YL-PYRROLIDINE;2-(1-NAPHTHYL)PYRROLIDINE
• CAS NO: 121193-91-7
• Molecular Formula: C14H15N
• Molecular Weight: 197.28
• Product Categories: Benzenes
• Mol File: 121193-91-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 346.78 °C at 760 mmHg
• Flash Point: 175.088 °C
• Appearance: Yellow/Liquid
• Density: 1.078 g/cm³
• Vapor Pressure: 5.63E-05mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-(Naphthalen-1-yl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Naphthalen-1-yl)pyrrolidine(121193-91-7)
• EPA Substance Registry System: 2-(Naphthalen-1-yl)pyrrolidine(121193-91-7)

Safety Data

• Hazardous Substances Data: 121193-91-7(Hazardous Substances Data)

Usage

Uses

2-(1-Naphthyl)pyrrolidine is used as pharmaceutical intermediate.

InChI:InChI=1/C14H15N/c1-2-7-12-11(5-1)6-3-8-13(12)14-9-4-10-15-14/h1-3,5-8,14-15H,4,9-10H2

Upstream product

• 123-75-1 pyrrolidine 
• 14474-59-0 naphthalen-1-yl-lithium 
• 86-53-3 1-Cyanonaphthalene 

Relevant articles and documents

Tf2O-Promoted Intramolecular Schmidt Reaction of the ω-Azido Carboxylic Acids

A designed Tf2O-promoted intramolecular Schmidt reaction of 2-substituted ω-azido carboxylic acids was demonstrated. Tf2O was used as an activation reagent for the carboxylic acid, and ω-azido anhydride was in situ generated, releasing a molecular TfOH, which acted as an acid promoter for the Schmidt process. A series of 2-substituted pyrrolidines was produced and acetylated for better purification. The strategy was also efficient for conversion of a 4-substituted ω-azido carboxylic acid to the tricyclic lactam.

Synthesis of 2-substituted pyrrolidines from nitriles

A novel and synthetically facile production of 2-substituted pyrrolidines from commercially available nitriles is reported herein. This methodology is operationally simple, and only requires the use of an extraction and a single chromatographic purificati