1212353-38-2

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its chiral nature allows for the creation of enantiomerically pure compounds, which is important in the development of new drugs.
Used in Organic Synthesis:
(2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate is used as a chiral building block in organic synthesis. Its ability to impart stereochemical control in chemical reactions makes it a valuable tool in the creation of complex organic molecules.
Used in Drug Development:
(2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate is being studied for its potential use in the development of new drugs. Its pharmacological properties are of interest to researchers, who are exploring its potential applications in various therapeutic areas.

Upstream product

• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 132482-10-1 (R)-1-<(1,1-dimethylethoxy)carbonyl>-2-pyrrolidinemethanolmethanesulfonate 
• 137496-71-0 2-methylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 104-15-4 toluene-4-sulfonic acid 
• 765-38-8 (S)-2-methylpyrrolidine 

Downstream Products

• 1132668-52-0 (S)-2-methyl-1-(4-nitro-3-(trifluoromethyl)phenyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis and evaluation of in vivo anti-hypothermic effect of all stereoisomers of the thyrotropin-releasing hormone mimetic: Rovatirelin Hydrate

We discovered the orally active thyrotropin-releasing hormone (TRH) mimetic: (4S,5S)-5-methyl-N-{(2S)-1-[(2R)-2-methylpyrrolidin-1-yl]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl}-2-oxo-1,3-oxazolidine-4-carboxamide 1 (rovatirelin). The central nervous system (CNS) effect of rovatirelin after intravenous (iv) administration is 100-fold higher than that of TRH. As 1 has four asymmetric carbons in its molecule, there are 16 stereoisomers. We synthesized and evaluated the anti-hypothermic effect of all stereoisomers of 1, which has the (4S),(5S),(2S),(2R) configuration from the N-terminus to the C-terminus, in order to clarify the structure?activity relationship (SAR) of stereoisomers. The (4R),(5R),(2R),(2S)-isomer 16 did not show any anti-hypothermic effect. Only the (4S),(5S),(2S),(2S)-isomer 10, which has the (2S)-2-methylpyrrolidine moiety at the C-terminus showed the anti-hypothermic effect similar to 1. Stereoisomers, which have the (5R) configuration of the oxazolidinone at the N-terminus and the (2R) configuration at the middle-part, showed a much lower anti-hypothermic effect than that of 1. On the other hand, stereoisomers, which have the (4R) configuration of the oxazolidinone at the N-terminus or the (2S) configuration of the C-terminus, have little influence on the anti-hypothermic effect.