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Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL is used as a building block in the synthesis of pharmaceutical drugs. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Agricultural Industry:
In the agricultural sector, (2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL is used as a building block in the synthesis of agrochemicals. Its incorporation into these products can enhance their effectiveness and selectivity.
Used in Chemical Research:
(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL serves as a reagent in chemical research, aiding scientists in understanding various chemical reactions and processes.
Used as a Precursor in Organic Compound Production:
(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL is also used as a precursor in the production of other organic compounds, contributing to the synthesis of a wide range of chemical products.
Used in Material Development:
(S)-Difluoroethanolamine has potential applications in the development of new materials, where its unique properties can be harnessed to create innovative and improved materials.
Used as a Catalyst in Chemical Reactions:
Furthermore, (2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL can be employed as a catalyst in chemical reactions, facilitating specific transformations and potentially increasing the efficiency of industrial processes.

Upstream product

• 1589473-76-6 (R)-4-benzyl-3-(2-(3,5-difluorophenyl)acetyl)oxazolidin-2-one 
• 1589473-77-7 (R)-4-benzyl-3-((R)-2-bromo-2-(3,5-difluorophenyl)acetyl)oxazolidin-2-one 
• 105184-38-1 3,5-difluorophenyl acetic acid 
• 1589473-78-8 (S)-3-((S)-2-azido-2-(3,5-difluorophenyl)acetyl)-4-benzyloxazolidin-2-one 
• 1589473-81-3 (S)-2-azido-2-(3,5-difluorophenyl)ethanol 
• 1260403-62-0 α-hydroxy-3,5-difluoroacetophenone 
• 1260403-64-2 4-(3,5-difluorophenyl)-5H-[1,2,3]-oxathiazole 2,2-dioxide 

Downstream Products

• 1589473-84-6 (S)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide 
• 1589473-85-7 (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide 
• 1589473-87-9 (S)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylthiophene-2-sulfonamide 
• 1589473-89-1 (S)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(prop-2-ynyl)thiophene-2-sulfonamide 
• 1589473-91-5 (S)-5-chloro-N-(cyclopropylmethyl)-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide 
• 1589473-93-7 (S)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(isobutylcarbamoyl)thiophene-2-sulfonamide 
• 1589473-95-9 (S)-methyl 2-(3-(5-chlorothiophen-2-ylsulfonyl)-3-((S)-1-(3,5-difluorophenyl)-2-hydroxyethyl)ureido)propanoate 
• 1589473-97-1 (S)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(prop-2-ynylcarbamoyl)thiophene-2-sulfonamide 
• 1589473-99-3 (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide 
• 1589474-01-0 (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(prop-2-ynyl)benzenesulfonamide 
• 1589474-03-2 (S)-4-chloro-N-(cyclopropylmethyl)-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide 
• 1589474-05-4 (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(isobutylcarbamoyl)benzenesulfonamide 
• 1589474-07-6 (S)-methyl 2-(3-(4-chlorophenylsulfonyl)-3-((S)-1-(3,5-difluorophenyl)-2-hydroxyethyl)ureido)propanoate 
• 1589474-09-8 (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-(prop-2-ynylcarbamoyl)benzenesulfonamide 

Relevant academic research and scientific papers

Enantioselective Access to Chiral Cyclic Sulfamidates Through Iridium-Catalyzed Asymmetric Hydrogenation

The Iridium-catalyzed asymmetric hydrogenation of cyclic sulfamidate imines was successfully developed with N-methylated ZhaoPhos L2 as the ligand. A variety of chiral cyclic sulfamidates were obtained with excellent results (up to 99% yield, 99% ee). Furthermore, this asymmetric hydrogenation can be employed as the key reaction step to prepare the important intermediates in organic synthesis. (Figure presented.).

Difluorophenylglycinols as New Modulators of Proteolytic Processing of Amyloid Precursor Proteins

Synthesis and evaluation of difluorophenylglycinols as new modulators of proteolytic processing of the amyloid-β precursor proteins for Alzheimer's therapies were described. A range of N-substituted (R)- and (S)- difluorophenylglycinols, structured on the amino alcohol framework, were explored by incorporating the arylsulfonyl moieties and various N-substituents. Evans' chiral auxiliary strategy was employed for the asymmetric synthesis of these enantiomeric difluorophenylglycinols. Compounds with effects on the γ-secretase inhibition and ERK-mediated signaling pathways were evaluated on cell-based assays. Among them, N-cyclopropylmethyl derivatives R-12c and R-13c showed modest γ-secretase inhibition as well as ERK-dependent activation. A range of N-substituted (R)- and (S)-difluorophenylglycinols, structured on the amino alcohol framework, were explored by incorporating the arylsulfonyl moieties and various N-substituents. Compounds with effects on γ-secretase inhibition and ERK-mediated signaling pathways were evaluated on cell-based assays. The N-cyclopropylmethyl derivatives R-12c and R-13c showed modest γ-secretase inhibition and ERK-dependent activation.