1260403-62-0

Usage

Uses

Used in Organic Synthesis:
α-hydroxy-3,5-difluoroacetophenone is utilized as a key building block in the creation of a wide range of pharmaceuticals, agrochemicals, and materials. Its unique chemical structure, including the presence of fluorine atoms, makes it particularly suitable for specific reactions in organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, α-hydroxy-3,5-difluoroacetophenone is used as an intermediate in the synthesis of various drugs. Its ability to be further modified and functionalized allows for the development of molecules with tailored properties for specific therapeutic applications.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, α-hydroxy-3,5-difluoroacetophenone serves as a precursor for the synthesis of compounds with pesticidal or herbicidal properties, leveraging its reactivity and structural features to create effective agents for agricultural use.
Used in Material Science:
α-hydroxy-3,5-difluoroacetophenone is also employed in material science for the development of new materials with specialized properties. α-hydroxy-3,5-difluoroacetophenone's capacity for functionalization enables the creation of materials with tailored characteristics for use in various applications, such as in coatings, adhesives, or advanced composites.

Upstream product

• 461-96-1 3,5-difluorobromobenzene 
• 13831-31-7 Acetoxyacetyl chloride 
• 1260403-63-1 α-acetoxy-3,5-difluoroacetophenone 

Downstream Products

• 957121-89-0 ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate 
• 957118-49-9 [3H]-MK 3207 
• 1260403-64-2 4-(3,5-difluorophenyl)-5H-[1,2,3]-oxathiazole 2,2-dioxide 
• 1260403-65-3 C₈H₇F₂NO₃S 
• 1260403-66-4 C₁₅H₂₀F₂N₂O₅S 
• 1260403-67-5 C₁₄H₁₆F₂N₂O 
• 957187-34-7 C₁₆H₁₈F₂N₂O₃ 
• 1212932-15-4 (S)-2-amino-2-(3,5-difluorophenyl)ethanol 

Relevant academic research and scientific papers

BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR

The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

Practical asymmetric synthesis of a chiral piperazinone derivative

A practical asymmetric route to a chiral piperazinone derivative, a fragment of MK-3207, is reported. The amine-bearing benzylic stereocenter is introduced via an asymmetric Pd-catalyzed hydrogenation of a cyclic sulfimidate in the presence of a chiral phosphine ligand. An efficient synthesis of the hydrogenation substrate is described, together with process development of the hydrogenation step and elaboration of the resulting cyclic sulfamate product to the desired piperazinone.

Synthesis of α-hydroxyacetophenones

A general method for the preparation of α-hydroxyacetophenones is presented. Functionalized arylmagnesium species are transmetalated to the corresponding arylzinc intermediates, which undergo Cu(I)-catalyzed reaction with acetoxyacetyl chloride. Acidic hy

PROCESS FOR MAKING CGRP RECEPTOR ANTAGONIST

The invention encompasses a novel process for making 2-[(8R)-8-(3,5-Difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]acetamide, which is a CGRP receptor antagonist useful for the treatment of migraine, using an asymmetric phase-transfer catalysis route. The invention also encompasses an efficient and practical synthesis of the (R)-acid intermediate, and generates the benzylic stereocenter in an enantioselective manner.