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1213-06-5

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1213-06-5 Usage

Description

N,N-Diethyl-4-sulfamoylbenzoic acid is a sulfonamide derivative, characterized by the presence of a sulfonyl group attached to a benzene ring, with two ethyl groups and a sulfamoyl group also attached to the ring. It is a white to off-white crystalline solid that exhibits stability under normal conditions. N,N-DIETHYL-4-SULFAMOYLBENZOIC ACID is recognized for its role as an intermediate in the synthesis of pharmaceuticals, leveraging its sulfonamide functionality, which is known for its biological activity and therapeutic potential.

Uses

Used in Pharmaceutical Synthesis:
N,N-Diethyl-4-sulfamoylbenzoic acid is used as an intermediate in the synthesis of various pharmaceuticals, particularly diuretic drugs. Its sulfonamide functionality contributes to the biological activity and therapeutic potential of the final drug products, making it a valuable component in medicinal chemistry.
Used in Diuretic Drug Development:
In the pharmaceutical industry, N,N-Diethyl-4-sulfamoylbenzoic acid is utilized as a key component in the development of diuretic medications. N,N-DIETHYL-4-SULFAMOYLBENZOIC ACID's structure and properties allow it to contribute to the efficacy of these drugs, which are designed to increase the amount of urine produced and excreted, thereby helping to remove excess water and salt from the body. This application is crucial for treating conditions like hypertension, heart failure, and kidney diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 1213-06-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,1 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1213-06:
(6*1)+(5*2)+(4*1)+(3*3)+(2*0)+(1*6)=35
35 % 10 = 5
So 1213-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO4S/c1-3-12(4-2)17(15,16)10-7-5-9(6-8-10)11(13)14/h5-8H,3-4H2,1-2H3,(H,13,14)/p-1

1213-06-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(diethylsulfamoyl)benzoic acid

1.2 Other means of identification

Product number -
Other names Ethebenecid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1213-06-5 SDS

1213-06-5Relevant articles and documents

Syntheses and biological activity of 2-(4'-diethylsulfonamide phenyl)-4-substituted aminomethyl-1,3,4-oxadiazolin-5-thiones

Havaldar, Freddy H.,Khatri, Navinchandra K.

, p. 453 - 456 (2008/02/12)

4-(Chlorosulfonyl) benzoic acid was condensed with diethyl amine to afford 4-(diethylsulfamoyl) benzoic acid 1 which was esterified to obtain methyl ester 2. The condensation of compound 2 with hydrazine hydrate gave hydrazino derivative 3. This intermediate undergoes cyclization with carbon disulphide and potassium hydroxide to yield substituted 1,3,4-oxadiazolin-5-thione 4. Aminomethylation of 4 using different amines furnished 4-substituted aminomethyl-2-(4'-diethylsulphonamide phenyl)-1,3,4-oxadiazolin-5-thiones 5a-e. The structure of the newly synthesized compounds have been established by analytical and spectral data. These compounds have also been screened for their biological activity.

Factors Which Influence the Formation of Oxadiazoles from Anthranilhydrazides and Other Benzoylhydrazines

Peet, Norton P.,Sunder, Shyam

, p. 1807 - 1816 (2007/10/02)

The cyclization of o-aminobenzoylhydrazine (1a) and its 5-methyl derivative 1b with four equivalents and with one equivalent of triethyl orthoacetate (TEOA) was studied. 3-Amino-2-methyl-4(3H)-quinazolinone (2a), 3,4-dihydro-2-methyl-5H-1,3,4-benzotriazepin-5-one (3a) and an imino ether derivative of 2a, N-ethanimidic acid ethyl ester (4a) were obtained from the reaction of 1a with four equivalents of TEOA.These results were compared with those of Merour who isolated 2a and 3a using the same conditions.When 1a was treated with one equivalent of TEOA, 2a, 3a, and a new product, 2-(5-methyl-1,3,4-oxadiazol-2-yl)benzenamine (5a) were produced, and 4a was not.Similar results were obtained with the reactions of 1b with TEOA.Authentic samples of oxadiazoles 5a and b were prepared by alternate routes.Novel acid-catalyzed rearrangements of benzotriazepinones 3a and b, to mixtures of aminoquinazolinones 2a and b and oxadiazoles 5a and b, respectively, were found.The different relative amounts of aminoquinazolinones 2 and oxadiazoles 5 which were produced from these rearrangements allowed us to choose between two potential mechanism for these interesting rearrangements.Treatment of 5-nitrobenzoylhydrazine (37) with four equivalents of TEOA gave three products which were characterized, but did not lead to benzotriazepinone formation.

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