5325-05-3

Upstream product

• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 1017238-72-0 ethyl 4-(N,N-diethylsulfinamoyl)benzoate 
• 10486-51-8 4-ethoxycarbonylbenzenesulfonyl chloride 
• 109-89-7 diethylamine 
• 64-17-5 ethanol 
• 1213-06-5 Antidipsin 

Downstream Products

• 53554-97-5 4-<(Diethylamino)sulfonyl>benzoic Acid Hydrazide 
• 96134-63-3 N,N-Diethyl-4-(5-ethyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide 
• 96134-62-2 N,N-Diethyl-4-(5-methyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide 
• 96134-61-1 N,N-Diethyl-4-[1,3,4]oxadiazol-2-yl-benzenesulfonamide 
• 96134-64-4 N,N-Diethyl-4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide 

Relevant academic research and scientific papers

Mild and general method for the synthesis of sulfonamides

Reaction of methyl sulfinates with lithium amides followed by 3-chloroperoxybenzoic acid oxidation of the resulting sulfinamides provides primary, secondary, and tertiary alkane-, arene-and heteroarenesulfonamides in high yields. This constitutes a mild and facile experimental protocol that avoids the use of hazardous, unstable, or volatile reagents and does not affect the configurational stability of the amines. Georg Thieme Verlag Stuttgart.

Facile one-pot synthesis of aromatic and heteroaromatic sulfonamides

A series of arene and heteroarene sulfonamides were prepared in one vessel from aryl and heteroaryl bromides via conversion into the corresponding Grignard reagents using either magnesium or isopropylmagnesium chloride and subsequent reaction with sulfur dioxide, sulfuryl chloride, and an amine.

Factors Which Influence the Formation of Oxadiazoles from Anthranilhydrazides and Other Benzoylhydrazines

The cyclization of o-aminobenzoylhydrazine (1a) and its 5-methyl derivative 1b with four equivalents and with one equivalent of triethyl orthoacetate (TEOA) was studied. 3-Amino-2-methyl-4(3H)-quinazolinone (2a), 3,4-dihydro-2-methyl-5H-1,3,4-benzotriazepin-5-one (3a) and an imino ether derivative of 2a, N-ethanimidic acid ethyl ester (4a) were obtained from the reaction of 1a with four equivalents of TEOA.These results were compared with those of Merour who isolated 2a and 3a using the same conditions.When 1a was treated with one equivalent of TEOA, 2a, 3a, and a new product, 2-(5-methyl-1,3,4-oxadiazol-2-yl)benzenamine (5a) were produced, and 4a was not.Similar results were obtained with the reactions of 1b with TEOA.Authentic samples of oxadiazoles 5a and b were prepared by alternate routes.Novel acid-catalyzed rearrangements of benzotriazepinones 3a and b, to mixtures of aminoquinazolinones 2a and b and oxadiazoles 5a and b, respectively, were found.The different relative amounts of aminoquinazolinones 2 and oxadiazoles 5 which were produced from these rearrangements allowed us to choose between two potential mechanism for these interesting rearrangements.Treatment of 5-nitrobenzoylhydrazine (37) with four equivalents of TEOA gave three products which were characterized, but did not lead to benzotriazepinone formation.