121392-35-6

Basic information

• Product Name: S-butyl 4-bromothiophenol
• Synonyms: (4-Bromophenyl)(butyl)sulfane;1-Bromo-4-butylthiobenzene;4-bromophenyl butyl sulfide;S-butyl 4-bromothiophenol
• CAS NO: 121392-35-6
• Molecular Formula: C₁₀H₁₃BrS
• Molecular Weight: 245.17922
• Mol File: 121392-35-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: S-butyl 4-bromothiophenol(CAS DataBase Reference)
• NIST Chemistry Reference: S-butyl 4-bromothiophenol(121392-35-6)
• EPA Substance Registry System: S-butyl 4-bromothiophenol(121392-35-6)

Safety Data

• Hazardous Substances Data: 121392-35-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
S-butyl 4-bromothiophenol is used as a building block for the synthesis of pharmaceutical drugs due to its unique structure and reactivity. It can be incorporated into the development of new medications with specific therapeutic properties.
Used in Materials Science:
In the field of materials science, S-butyl 4-bromothiophenol is utilized for its potential applications in the development of new materials with specific properties. Its unique structure allows for the creation of materials with tailored characteristics for various applications.
Used in Agrochemicals:
S-butyl 4-bromothiophenol may have potential uses in the field of agrochemicals, where it could be employed as a component in the development of new pesticides or other agricultural chemicals.
Used as a Precursor in Industrial Chemical Production:
Additionally, S-butyl 4-bromothiophenol serves as a precursor in the production of various industrial chemicals. Its unique structure and reactivity make it a valuable starting point for the synthesis of a range of chemical products.

Upstream product

• 1126-80-3 (n-butylthio)benzene 
• 109-65-9 1-bromo-butane 
• 106-53-6 para-bromobenzenethiol 
• 1207372-98-2 butyl 2-[2-(4-methoxyphenyl)ethynyl]benzoate 
• 629-45-8 dibutyl disulfide 
• 589-87-7 1,4-bromoiodobenzene 
• 542-69-8 1-iodo-butane 
• 109-79-5 n-butanethiol 

Downstream Products

• 3226-41-3 4-bromobenzenediazonium tetrafluoroborate 
• 151588-38-4 (4-(butylthio)phenyl)boronic acid 
• 1415309-92-0 C₁₆H₂₅BO₂S 
• 1415309-78-2 C₁₄H₁₇N₃OS 
• 1373154-07-4 (R)-1-bromo-4-(butylsulfinyl)benzene 
• 403793-28-2 (4-bromo-phenyl)-butyl sulfone 
• 1210812-41-1 2-(4-butylsulfanylphenylsulfanyl)phenylamine 
• 294895-76-4 1-(2-aminopyrimidin-5-yl)-2-(4-butylsulfanylphenyl)ethyne 
• 294895-71-9 3-(4-butylsulfanylphenyl)propiolic acid 
• 223399-81-3 1-(4-aminophenyl)-2-(4-butylsulfanylphenyl)ethyne 
• 294895-70-8 4-butylsulfanylphenylethyne 
• 294895-69-5 1-butylsulfanyl-4-(3-hydroxy-3-methylbut-1-ynyl)benzene 

Relevant articles and documents

Alkoxylation reactions of aryl halides catalyzed by magnetic copper ferrite

Copper ferrite (CuFe2O4), which is easy-made, air-stable, low cost, easy separable, and regenerable, was applied as catalyst in an efficient method for C-O coupling reactions between various kinds of unactivated alkyl alcohols and aryl halides. This method only adopts 2.5% mol CuFe2O4 catalyst and selectively proceeds to C-O bond formation even sensitive substituents exist in the system.

Gold-catalyzed C-S bond formation from thiols

ortho-Alkynylbenzoic acid alkyl esters act as alkylating agents of thiol derivatives with PPh3AuCl in combination with AgOTf in 1,2-dichloroethane at 80 °C. The corresponding sulfide compounds are obtained in good to excellent yields.

Recyclable heterogeneous supported copper-catalyzed coupling of thiols with aryl halides: base-controlled differential arylthiolation of bromoiodobenzenes

Alumina-supported copper sulfate efficiently catalyzes the 5-arylation of aromatic, heteroaromatic and aliphatic thiols with aryl as well as heteroaryl halides under aerobic, ligand-free conditions. This protocol provides an easy access to a variety of thioethers as well as unsymmetrical bis-thioethers by base-controlled differential coupling of thiols with iodo- and bromo-substituents in an aromatic halide. The catalyst is inexpensive, non-air sensitive, environmentally friendly and recyclable.

Methods for formation of aryl-sulfur and aryl-selenium compounds using copper(I) catalysts

A mild, palladium-free synthetic protocol for the cross-coupling reaction of vinyl or aryl iodides and thiols or selenols using, in certain embodiments, 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 ° C. A variety of vinyl/aryl sulfides and vinyl/aryl selenides can be synthesized in excellent yields from readily available iodides and thiols or selenols.

A mild and efficient copper-catalyzed coupling of aryl iodides and thiols using an oxime-phosphine oxide ligand

A mild and efficient copper-catalyzed system for the coupling of aryl iodides and thiols was developed using a readily prepared and highly stable oxime-phosphine oxide ligand. Good to excellent yields were obtained.

Alkyl- or arylthiolation of aryl iodide via cleavage of the S-S bond of disulfide compound by nickel catalyst and zinc

Various aryl sulfides can be synthesized by nickel-catalyzed alkyl- or arylthiolation of aryl iodide with a disulfide compound. This reaction produces Ni(0) from NiBr2-bpy by the reduction with zinc, and this generated complex works as an activating species to convert ArI into ArSR under neutral conditions. Furthermore, this system enables the use of two RS groups in (RS)2.

High birefringence nematic liquid crystals for display and telecom applications

Several compounds with high birefringence and, having tolane structure were synthesized. For a high polarizability, isothiocyanato (NCS) terminal group was introduced. Another goal of this study was reduction of melting point and smectic phases by introduction of fluorine as lateral substituent. The transition temperatures for all the synthesized compounds and the refractive and dielectric indices for one of the compounds have been determined. Electro-optic (EO) measurements were also performed.

Imidazolo-5-YL-2anilino-pyrimidines as agents for the inhibition of the cell proliffration

Compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

DERIVATIVES OF 4- (IMIDAZOL-5-YL)-2-(4-SULFOANILINO) PYRIMIDINE WITH CDK INHIBITORY ACTIVITY

Compounds of the formula (I): wherein R1, R2, R3, R4, R5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

A general method for the formation of aryl-sulfur bonds using copper(I) catalysts.

[reaction: see text] We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 degrees C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.