1214028-21-3Relevant articles and documents
Use of β-Methylphenylalanine (βMeF) Residues To Probe the Nature of the Interaction of Substance P with Its Receptor: Effects of βMeF-Containing Substance P Analogs on Rabbit Iris Smooth Muscle Contraction
Birney, David M.,Cole, Derek C.,Crosson, Craig E.,Kahl, Brenda F.,Neff, Bart W.,et al.
, p. 2478 - 2482 (1995)
The effects of substituting (2S,3S)-β-methylphenylalanine (S-βMeF) or (2S,3R)-β-methylphenylalanine (R-βMeF) for the Phe7 and/or Phe8 residues of the tachykinin substance P (SP, RPKPQQFFGLM-NH2) upon the ability of SP to stimulate co
(2R,1'S,2'R)- And (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl] alanines and their incorporation into hormaomycin analogues
De Meijere, Armin,Kozhushkov, Sergei I.,Yufit, Dmitrii S.,Grosse, Christian,Kaiser, Marcel,Raev, Vitaly A.
, p. 2844 - 2857 (2015/02/19)
Efficient and scalable syntheses of enantiomerically pure (2 R ,1' S ,2' R )- and (2 S ,1' S ,2' R )-3-[2-mono(di,tri)fluoromethylcyclopropyl] alanines 9a - c , as well as allo-D-threonine ( 4 ) and ( 2 S,3R)-β-methylphenylalanine (3), using the Belokon' approach with (S )- and (R )-2-[( N-benzylprolyl)amino]benzophenone [(S)- and (R)-10 ] as reusable chiral auxiliaries have been developed. Three new fluoromethyl analogues of the naturally occurring octadepsipeptide hormaomycin ( 1 ) with (fluoromethylcyclopropyl) alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity.
