121469-38-3Relevant academic research and scientific papers
NOVEL ENANTIOSELECTIVE SYNTHESIS OF PLATELET ACTIVATING FACTOR AND ITS ENANTIOMER VIA RING OPENING OF GLYCIDYL TOSYLATE WITH 1-HEXADECANOL
Guivisdalsky, Pedro N.,Bittman, Robert
, p. 4393 - 4396 (1988)
(2R)-and(2S)-Glycidyl tosylates 3 and 3' were used to synthesize platelet activating factor 1 and its enantiomer 2 in very high optical purity via the ring-opened ether-linked glycerol tosylate 4 and 4'
Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue
Andresen, Thomas L.,Jensen, Simon S.,Madsen, Robert,J?rgensen, Kent
, p. 7305 - 7314 (2007/10/03)
The clinical use of anticancer lipids is severely limited by their ability to cause lysis of red blood cells prohibiting intravenous injection. Novel delivery systems are therefore required in order to develop anticancer ether lipids (AELs) into clinicall
An Efficient Stereocontrolled Route to Both Enantiomers of Platelet Activating Factor and Analogues with Long-Chain Esters at C2: Saturated and Unsaturated Ether Glycerolipids by Opening of Glycidyl Arenesulfonates
Guivisdalsky, Pedro N.,Bittman, Robert
, p. 4643 - 4648 (2007/10/02)
Both enantiomers of various ether/ester glycerophospholines (R)- and (S)-1, including platelet activating factor (PAF, 2), have been synthesized from arenesulfonate derivatives of glycidol ((R)- and (S)-3) that are readily available in high enantiomeric p
