84415-89-4

Upstream product

• 17618-04-1 2,5-di-O-benzyl-D-mannitol 
• 91326-86-2 16-<(2S)-(2,3-(isopropylidenedioxy)propyl)oxy>hexadecane 
• 91326-85-1 2-O-benzyl-1-O-hexadecyl-3-O-trityl-sn-glycerol 
• 100-52-7 benzaldehyde 
• 103708-44-7 Methanesulfonic acid (S)-3-benzyloxy-4-hexadecyloxy-butyl ester 
• 103708-45-8 C₃₃H₅₂O₂Se 
• 103708-38-9 (S,S)-2-Phenyl-4-hexadecyloxymethyl-1,3-dioxane 
• 103773-80-4 ((S)-1-Hexadecyloxymethyl-allyloxymethyl)-benzene 
• 92775-64-9 (S)-2-O-Benzyl-1-O-hexadecyl-1,2,4-butanetriol 
• 103773-79-1 [(2S,4S)-2-phenyl-1,3-dioxan-4-yl]methanol 
• 100-51-6 benzyl alcohol 
• 17674-16-7 benzyl triflate 
• 112-82-3 hexadecanyl bromide 
• 137540-93-3 2,5-Di-O-benzyl-1,6-di-O-hexadecyl-3,4-O-isopropyliden-D-mannit 

Downstream Products

• 96924-84-4 Phosphorochloridic acid (R)-2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester 
• 91326-84-0 1-O-hexadecyl-2-O-benzyl-sn-glycero-3-phosphocholine 
• 91021-63-5 C₂₈H₅₆NO₇P 
• 130189-84-3 2-((R)-2-Benzyloxy-3-hexadecyloxy-propoxy)-[1,3,2]dioxaphospholane 2-oxide 
• 88587-94-4 L-1-hexadecyl-2-palmitoyl-phosphatidylcholine 
• 52691-62-0 1-palmityl-sn-glycero-3-phosphocholine 
• 1026421-63-5 Phosphoric acid (R)-2-benzyloxy-3-hexadecyloxy-propyl ester (S)-2,3-dihydroxy-propyl ester 
• 871693-86-6 1-O-hexadecyl-2-O-benzyl-sn-glycero-3-[phospho-N-Boc-ethanolamine] methyl ester 
• 74389-68-7 PAF 

Relevant academic research and scientific papers

ANTIVIRAL PRODRUGS, PHARMACEUTICAL FORMULATIONS, AND METHODS

Compounds, including antiviral prodrugs, and pharmaceutical formulations including the compounds, which may be orally bioavailable or formulated for intramuscular injection. Methods for producing compounds, such as antiviral prodrugs. Methods for treating coronavirus and other RNA virus infection in mammals. Methods of producing a drug triphosphate.

Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue

The clinical use of anticancer lipids is severely limited by their ability to cause lysis of red blood cells prohibiting intravenous injection. Novel delivery systems are therefore required in order to develop anticancer ether lipids (AELs) into clinicall

New optically pure dimethylacetals of glyceraldehydes and their application for lipid and phospholipid synthesis

A convenient synthesis of new and enantiometrically pure 2-O-protected D-glyceraldehyde dimethylacetals as chiral C-3 building blocks for the synthesis of lipids and phospholipids is described.Benzyl- or allylethers are used as protecting groups in position 2 and 5 of D-mannitol.These intermediates are converted to 2-O-benzyl- or 2-O-alkyl-D-glyceraldehyde dimethylacetals by cleavage with periodic acid in methanol.The two dimethylacetals are useful for the synthesis of mixed chain phospholipids with natural configuration of ester-ester, ester-ether or ether-ether composition.Also, triglycerides with three different alkyl chains, ester of ether, can be prepared.As an example of the varsatility of the new intermediates, we describe the synthesis of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocho;ine, the so-called 'platelet activating factor' (PAF), via 1-O-hexadecyl-2-O-benzyl-sn-glycerol. Keywords: Synthetic phospholipids; PAF; Phospholipid analogues; Synthesis; Chiral pool; Glyceraldehyde; C-3 building blocks; Optical purity

Stereoselective Synthesis of 2-O-Benzyl-1-O-hexadecyl-sn-glycerol

Due to the versatility of 2-O-benzyl-1-O-hexadecyl-sn-glycerol (7) as building block for various alkyl ether lipids and alkyl ether lyso-lipids, 7 was prepared from D-mannit following two different strategies.The final product 7 was obtained either via th

Syntheses of a glycerophospholipid, C16-platelet activating factor and a palmitoyl analogue of M-5, an anti-inflammatory glyceroglycolipid

From a chiral C4-epoxide (-)-3, which is one of the synthons in our synthetic strategy for complex lipids, a glycerophospholipid C16-platelet activating factor (C16-PAF, 1) and a palmitoyl analogue (2) of an anti-inflammatory glyceroglycolipid M-5, which was previously isolated from the Okinawan marine sponge Phyllospongia foliascens, have been synthesized.

An Efficient Stereocontrolled Route to Both Enantiomers of Platelet Activating Factor and Analogues with Long-Chain Esters at C2: Saturated and Unsaturated Ether Glycerolipids by Opening of Glycidyl Arenesulfonates

Both enantiomers of various ether/ester glycerophospholines (R)- and (S)-1, including platelet activating factor (PAF, 2), have been synthesized from arenesulfonate derivatives of glycidol ((R)- and (S)-3) that are readily available in high enantiomeric p

NOVEL ENANTIOSELECTIVE SYNTHESIS OF PLATELET ACTIVATING FACTOR AND ITS ENANTIOMER VIA RING OPENING OF GLYCIDYL TOSYLATE WITH 1-HEXADECANOL

(2R)-and(2S)-Glycidyl tosylates 3 and 3' were used to synthesize platelet activating factor 1 and its enantiomer 2 in very high optical purity via the ring-opened ether-linked glycerol tosylate 4 and 4'