1215-53-8

Basic information

• Product Name: 3-pyridylformaldehyde benzoylhydrazone
• Synonyms: 3-pyridylformaldehyde benzoylhydrazone
• CAS NO: 1215-53-8
• Molecular Weight: 225.25
• Mol File: 1215-53-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-pyridylformaldehyde benzoylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-pyridylformaldehyde benzoylhydrazone(1215-53-8)
• EPA Substance Registry System: 3-pyridylformaldehyde benzoylhydrazone(1215-53-8)

Safety Data

• Hazardous Substances Data: 1215-53-8(Hazardous Substances Data)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 93-89-0 benzoic acid ethyl ester 
• 65-85-0 benzoic acid 

Downstream Products

• 77420-79-2 1-chloro-1-phenyl-4-(3-pyridyl)-2,3-diazabutadiene hydrochloride 
• 21398-08-3 3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridine 
• 1010796-52-7 N'-(1-(pyridin-3-yl)but-3-enyl)benzohydrazide 
• 1192113-44-2 (R)-N'-[1-(pyridin-3-yl)but-3-enyl]benzohydrazide 

Relevant articles and documents

A convenient synthesis and biological activities of N-(pyridin-3-ylmethylene) benzohydrazides by the condensation of nicotinaldehydes with benzohydrazides

Series of N'-(pyridine-3-ylmethylene)benzohydrazides 3a-y have been prepared by the condensation of nicotinaldehydes 1a-e with benzohydrazides 2a-e in the presence of glacial AcOH in ethanol at room temperature. Total twenty five compounds have been prepa

Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs

Abstract Schiff base derivatives have recently been shown to possess antimicrobial activity, and these derivatives include a limited number of salicylaldehyde hydrazones. To further explore this structure-activity relationship between salicylaldehyde hydrazones and antifungal activity, we previously synthesized and analyzed a large series of salicylaldehyde and formylpyridinetrione hydrazones for their ability to inhibit fungal growth of both azole-susceptible and azole-resistant species of Candida. While many of these analogs showed excellent growth inhibition with low mammalian cell toxicity, their activity did not extend to azole-resistant species of Candida. To further dissect the structural features necessary to inhibit azole-resistant fungal species, we synthesized a new class of modified salicylaldehyde derivatives and subsequently identified a series of modified pyridine-based hydrazones that had potent fungicidal antifungal activity against multiple Candida spp. Here we would like to present our synthetic procedures as well as the results from fungal growth inhibition assays, mammalian cell toxicity assays, time-kill assays and synergy studies of these novel pyridine-based hydrazones on both azole-susceptible and azole-resistant fungal species.

Fast synthesis of N-acylhydrazones employing a microwave assisted neat protocol

A variety of N-acylhydrazones were synthesized under microwave irradiation within 2.5-10 min, starting from benzo, salicyloyl, and isonicotinic hydrazides. The protocol developed employs microwave irradiation in the absence of solvents and catalysts, lead