1215006-07-7Relevant academic research and scientific papers
Asymmetric synthesis of linezolid thiazolidine-2-thione derivatives via CS2 mediated decarboxylation cyclization
Bai, Meng-Meng,Cai, Jianfeng,Cui, De-Yun,Kong, Hong-Tao,Qu, Ying-Long,Shen, Bo-Yuan,Yan, Da-chao,Yang, Yi,Zhang, En,Zhang, Xiu-Juan
supporting information, (2020/04/08)
A mild and cost-effective decarboxylation cyclization method was developed for the synthesis of chiral 5-substituted thiazolidine-2-thione derivatives from β-amino oxazolidinones. This reaction was mediated by CS2 and allowed a highly stereoselective synthesis of linezolid thiazolidine-2-thione derivatives. The chirality of the linezolid base was completely retained in the final product.
Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
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Page/Page column 8, (2010/04/24)
Comprising a preparation process of linezolid from a compound of formula (IV) where R1 is selected from a (C4-C10)-alkyl radical which is attached to the N atom by a tertiary C atom, and a straight or branched (C3-C10)-alkenyl radical attached to the N atom such that the C=C double bond is separated from the N atom by a methylene group. Compound (IV) is submitted either first to an acetylation reaction and then to a dealkylation reaction or, alternatively, first to a dealkylation reaction and then to an acetylation reaction to yield linezolid. It also comprises new intermediate compounds useful in such a preparation process, which are obtained with high yields and high chemical and optical purity, and which are processed easily to linezolid.
