1215006-52-2Relevant academic research and scientific papers
Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration
Dao, Viet Hung,Ourliac-Garnier, Isabelle,Bazin, Marc-Antoine,Jacquot, Catherine,Baratte, Blandine,Ruchaud, Sandrine,Bach, Stéphane,Grovel, Olivier,Le Pape, Patrice,Marchand, Pascal
, p. 2250 - 2255 (2018)
In a context of growing resistance to classical antifungal therapy, the design of new drugs targeting alternative pathways is highly expected. Benzofuro[3,2-d]pyrimidine derivatives, derived from (?)-cercosporamide, were synthesized and evaluated as potential Candida albicans PKC inhibitors in the aim of restoring susceptibility to azole treatment. Co-administration assay of benzofuropyrimidinedione 23 and fluconazole highlighted a synergistic effect on inhibition of cell growth of a Candida albicans resistant strain.
Regioselective reactions of highly substituted arynes
Tadross, Pamela M.,Gilmore, Christopher D.,Bugga, Pradeep,Virgil, Scott C.,Stoltz, Brian M.
supporting information; experimental part, p. 1224 - 1227 (2010/06/13)
"Chemical Equation Presented" The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/ condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functlonallzation of aromatic rings.
