2999-40-8

Usage

Uses

Used in Pharmaceutical Industry:
Phloroglucinol triacetate is used as a pharmaceutical intermediate for the production of antispasmodic drugs. It helps in the synthesis of these drugs, which are used to relieve muscle spasms and cramps.
Used in Organic Synthesis:
Phloroglucinol triacetate is used as a reducing agent in organic synthesis. Its ability to protect against oxidative stress makes it a valuable compound in the synthesis of various organic compounds.
Used in Fragrance Industry:
Phloroglucinol triacetate has potential applications in the synthesis of fragrances. Its unique chemical properties contribute to the creation of various scent profiles in the fragrance industry.
Used in Dye Industry:
Phloroglucinol triacetate is also used in the synthesis of dyes. Its versatile chemical reactivity allows for the development of a wide range of dyes with different color properties.

Upstream product

• 463-51-4 Ketene 
• 108-73-6 3,5-dihydroxyphenol 
• 127-09-3 sodium acetate 
• 75-36-5 acetyl chloride 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 108-24-7 acetic anhydride 
• 117-39-5 quercetol 
• 528-58-5 cyanidin chloride 
• 108-22-5 Isopropenyl acetate 
• 621-23-8 1,2,3-trimethoxybenzene 
• 64-19-7 acetic acid 
• 89475-38-7 2,3',4,4',6-Pentaacetoxy-chalkon 
• 717-74-8 1,3,5-triisopropyl benzene 

Downstream Products

• 2161-87-7 1,3,5-triacetyl-2,4,6-trihydroxybenzene 
• 2161-86-6 2,4-diacetylphloroglucinol 
• 4328-17-0 trinitrophloroglucinol 
• 621-23-8 1,2,3-trimethoxybenzene 
• 124607-18-7 5,7-dihydroxy-4-(4-hydroxyphenyl)-2H-1-benzopyran-2-one 
• 97776-01-7 5,7-dihydroxy-4'-benzyloxy-4-phenylcoumarin 
• 17820-33-6 acetic acid 5-acetoxy-2-acetyl-3-hydroxyphenyl ester 
• 104654-31-1 5-acetoxy-2,4-diacetyl-1,3-dihydroxybenzene 
• 133649-23-7 <(15)N3>Trinitrophloroglucinol 
• 59434-20-7 1,3,5-tri-O-benzylphloroglucinol 
• 108-73-6 3,5-dihydroxyphenol 
• 908864-75-5 5-benzyloxy-2-iodo-benzene-1,3-diol 
• 850399-67-6 1,3-di-O-acetyl-5-O-benzyl-benzophenone 
• 908864-77-7 trifluoro-methanesulfonic acid 5-benzyloxy-3-hydroxy-2-iodo-phenyl ester 

Relevant academic research and scientific papers

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE

Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

Protection of COOH and OH groups in acid, base and salt free reactions

We report an iron-catalyzed general functional group protection method with inexpensive reagents. This environmentally benign process does not use acids or bases, and does not produce waste products. Further purification beyond filtration and evaporation is, in most cases, unnecessary. Free COOH and OH groups can be protected in a one-pot reaction.

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration

In a context of growing resistance to classical antifungal therapy, the design of new drugs targeting alternative pathways is highly expected. Benzofuro[3,2-d]pyrimidine derivatives, derived from (?)-cercosporamide, were synthesized and evaluated as potential Candida albicans PKC inhibitors in the aim of restoring susceptibility to azole treatment. Co-administration assay of benzofuropyrimidinedione 23 and fluconazole highlighted a synergistic effect on inhibition of cell growth of a Candida albicans resistant strain.

The synthesis of lactone-bridged 1,3,5-triphenylbenzene derivatives as pi-expanded coumarin triskelions

Two triply lactone-bridged 1,3,5-triphenylbenzene derivatives with solubilizing moieties have been synthesized in five and six steps from commercially available starting materials. Compounds containing the 1,3,5-triphenylbenzene core with two atom bridges are relatively unknown. This new class of pi-expanded coumarins contain triskelion architectures and X-ray crystallographic studies of one of the triskelions indicates that the 1,3,5-triphenylbenzene core adopts a near-planar geometry. This is the only known example of a two atom-bridged 1,3,5-triphenylbenzene derivative to adopt a planar structure.

Synthesis and antibacterial activity of new symmetric polyoxygenated dibenzofurans

A series of symmetric polyoxygenated dibenzofurans with 2-methylbutyril moieties at C-4 and C-6 were obtained from commercial phloroglucinol through a sequence of reactions that include monoacylation, iodination, Suzuki-Miyaura coupling, oxidative dimeriz

Microwave-assisted acetylation of phenols without catalyst under solvent free condition

Etherification between phenols with acetic anhydride was tested under different conditions. Phenols were efficiently acylated with acetic anhydride to give phenol acetate derivatives in good high yields without catalyst and solventless conditions under microwave irradiation.

Synthesis and antiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines

A novel series of 3-methyl-1-benzofuran derivatives were synthesized and screened in vitro for their antiproliferative activity against two human NSCLC cell lines (NSCLC-N6 mutant p53 and A549 wild type p53). Most promising compounds presented a structural analogy with the west part of cercosporamide, a natural product of biological interest. In particular, compounds 10, 12 and 31 showed cytotoxic activities at micromolar concentrations (IC50 50 values (25-40 μM).

SYNTHESIS OF CATECHIN AND EPICATECHIN CONJUGATES

The present invention relates generally to catechin and epicatechin conjugates of formula (I). For example, a chemical synthesis process for the preparation of catechin and epi-catechin compounds, in particular of catechin and epi-catechin conjugates is disclosed. A further aspect of the invention pertains to new catechin and epi-catechin conjugate compounds.

Synthesis of catechin and epicatechin conjugates

The present invention relates generally to catechin and epicatechin conjugates of formula (I). For example, a chemical synthesis process for the preparation of catechin and epi-catechin compounds, in particular of catechin and epi-catechin conjugates is disclosed. A further aspect of the invention pertains to new catechin and epi-catechin conjugate compounds.

Synthesis and evaluation of benzophenone O-glycosides as α-glucosidase inhibitors

The first total synthesis of benzophenone O-glycosides (iriflophenone 2-O-α-L-rhamnopyranoside: 1 and aquilarisinin: 2) isolated from the leaves of Aquilaria sinensis and related new derivatives (3-12) was accomplished through suitable protecting group ma