121505-97-3Relevant academic research and scientific papers
Improved syntheses of α-BOC-aminoketones from α-BOC-amino-Weinreb amides using a pre-deprotonation protocol
Liu, Jinchu,Ikemoto, Norihiro,Petrillo, Daniel,Armstrong III, Joseph D.
, p. 8223 - 8226 (2002)
A general procedure was developed to prepare α-BOC-aminoketones in good yields from α-BOC-amino Weinreb amides containing an exchangeable amino proton. By first deprotonating this amino group using 1 equiv. of a simple alkyl Grignard base, only a stoichio
SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS
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, (2021/05/21)
The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.
A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine
Huang, Wei,Ma, Jing-Yi,Yuan, Mu,Xu, Long-Fei,Wei, Bang-Guo
experimental part, p. 7829 - 7837 (2011/10/12)
An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride 3 and antiangiogenic streptopyrrolidine 4. Compared four s
A NEW SYNTHESIS OF N-PROTECTED α-AMINOMETHYL KETONES FROM GLYCINE
Davies, David T.,O'Hanlon, Peter J.
, p. 2273 - 2280 (2007/10/02)
N-Protected α-aminomethyl ketones can be prepared by reaction of glycine derivatives with various carbanions.
