1215081-95-0

Basic information

• Product Name: 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
• Synonyms: 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
• CAS NO: 1215081-95-0
• Molecular Weight: 445.401
• Mol File: 1215081-95-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide(1215081-95-0)
• EPA Substance Registry System: 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide(1215081-95-0)

Safety Data

• Hazardous Substances Data: 1215081-95-0(Hazardous Substances Data)

Upstream product

• 1089725-58-5 tert-butyl N-tert-butoxycarbonyl-N-[4-nitro-2-(trifluoromethyl)phenyl]carbamate 
• 121-01-7 4-nitro-2-trifluoromethyl-aniline 
• 1089725-60-9 tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate 
• 75-44-5 phosgene 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 

Relevant articles and documents

Protein Kinase Conjugates and Inhibitors

The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kin

ALGORITHM FOR DESIGNING IRREVERSIBLE INHIBITORS

The invention is an algorithm and method for designing an inhibitor that covalently binds a target polypeptide. The algorithm and method can be used to rapidly and efficiently convert reversible inhibitors into irreversible inhibitors.