121517-97-3

Upstream product

• 58-61-7 adenosine 
• 121517-97-3 2',3'-Di-O-acetyl-5'-fluoro-5'-S-(4-methoxyphenyl)-5'-thioadenosine 
• 137103-06-1 5'-S-(4-methoxyphenyl)-5'-thioadenosine 
• 144493-94-7 2',3'-di-O-acetyl-5'-S-(4-methoxyphenyl)-5'-thioadenosine 
• 121517-95-1 2',3'-di-O-acetyl-5'-deoxy-5'-<(4-methoxyphenyl)sulfinyl>adenosine 
• 696-63-9 4-Methoxybenzenethiol 
• 108-24-7 acetic anhydride 
• 121540-26-9 5'(S)-Fluoro-5'-S-(4-methoxyphenyl)-5'-thioadenosine 
• 892-48-8 5'-deoxy-5'-chloroadenosine 

Downstream Products

• 121540-26-9 5'(S)-Fluoro-5'-S-(4-methoxyphenyl)-5'-thioadenosine 
• 121517-98-4 5'-Fluoro-5'-S-(4-methoxyphenyl)-5'-thioadenosine 

Relevant academic research and scientific papers

Nucleic acid related compounds. 80. Synthesis of 5'-S-(alkyl and aryl)-5'-fluoro-5'-thioadenosines with Xenon difluoride or (diethylamido)sulfur trifluoride, hydrolysis in aqueous buffer, and inhibition of S-adenosyl-L-homocysteine hydrolase by derived 'a

Treatment of 5'-S-(alkyl and aryl)-5'-thioadenosine derivatives 2 with XeF2, or the corresponding sulfoxides 3 with DAST/SbCl3, gave diastereomeric 5'-fluoro compounds which were deprotected to give the 5'-S-(alkyl and aryl)-5'-fluor

Efficient Conversions of Thioethers to α-Fluoro Thioethers with DAST or DAST/Antimony(III) Chloride

Dialkyl or alkyl aryl thioethers, including nucleoside thioethers, undergo virtually quantitative conversion to α-fluoro thioethers with (diethylamino)sulfur trifluoride (DAST) in dichloromethane at ambient temperature.Antimony(III) chloride catalyzes the process.