1215208-64-2Relevant academic research and scientific papers
AROYLQUINOLINE COMPOUNDS
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, (2011/11/13)
A serious of nitro heterocyclic derivatives including a structure of formula (I) are provided. In formula (I), P, Q and R1 to R8 are defined in the specification. The derivatives disclosed in the present invention are characterized in inhibiting tubulin p
5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors
Nien, Chih-Ying,Chen, Yun-Ching,Kuo, Ching-Chuan,Hsieh, Hsing-Pang,Chang, Chi-Yen,Wu, Jian-Sung,Wu, Su-Ying,Liou, Jing-Ping,Chang, Jang-Yang
supporting information; experimental part, p. 2309 - 2313 (2010/08/07)
A series of aroylquinoline derivatives were synthesized and evaluated for anticancer activity. 5-Amino6-methoxy-2-aroylquinoline 15 showed more potent antiproliferative activity (IC50 values ranging from 0.2 to 0.4 nM) as compared to la (combretastatin A-4) (IC50 = 1-9-835 nM) against various human cancer cell lines and a MDR-resistant cancer cell line. Compound 15 (IC50 = 1-6 μM) exhibited more potent inhibition of tubulin polymerization than la (IC50 = 2.1 μM) and showed strong binding property to the colchicine binding site of microtubules.
