121624-77-9

Upstream product

• 20725-25-1 1,3-bis(4-chlorophenyl)prop-2-en-1-one 
• 109-77-3 malononitrile 
• 1174016-84-2 5,7‐bis(4‐chlorophenyl)‐tetrazolopyridine‐8‐carbonitrile 
• 99-91-2 para-chloroacetophenone 
• 133707-66-1 4,6-bis-(4-chloro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 1416954-76-1 ethyl 2-(4,6-bis(4-chlorophenyl)-3-cyanopyridin-2-yloxy)acetate 
• 631-61-8 ammonium acetate 
• 104-88-1 4-chlorobenzaldehyde 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 1370255-97-2 1-[4,6-bis-(4-chlorophenyl)-3-cyanopyridin-2-yl]5-oxopyrrolidine-3-carboxylic acid 
• 446311-93-9 4,6-bis(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 
• 7440-44-0 pyrographite 
• 138744-64-6 5,7-Bis-(4-chloro-phenyl)-2-piperidin-1-ylmethyl-3H-pyrido[2,3-d]pyrimidin-4-one 
• 138744-61-3 2-Chloromethyl-5,7-bis-(4-chloro-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one 
• 138744-67-9 5,7-Bis-(4-chloro-phenyl)-2-methyl-3H-pyrido[2,3-d]pyrimidin-4-one 
• 138744-58-8 N-[4,6-Bis-(4-chloro-phenyl)-3-cyano-pyridin-2-yl]-2-chloro-acetamide 
• 145208-69-1 4-Amino-5,7-bis-(4-chloro-phenyl)-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 138744-49-7 2,4-Bis-(4-chloro-phenyl)-6,7,8,9-tetrahydro-benzo[b][1,8]naphthyridin-5-ylamine 
• 138744-54-4 5,7-Bis-(4-chloro-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one 
• 138744-52-2 5,7-Bis-(4-chloro-phenyl)-1H-pyrido[2,3-d]pyrimidine-2,4-dithione 

Relevant academic research and scientific papers

Synthesis, characterization, DFT modeling and biological studies of new Co(II), Ni(II) and Cu(II) 4,6-bis(4-chlorophenyl)-2-amino-1,2-dihydropyridine-3-carbinitrile complexes

Three new metal complexes of 4,6-bis(4-chlorophenyl)-2-amino-1,2-dihydropyridine-3-carbinitrile (L) with Co(II), Ni(II) and Cu(II) were synthesized and characterized with physicochemical and spectroscopic techniques. The data suggest that (L) acts as a bidentate ligand bound to the divalent metal ions through amino N and carbinitrile N atoms having [M(L)2(H2O)2]2+ formula (M?=?metal ions). The theoretical parameters, model structures, charges and molecular orbitals of all possible complexes have been determined using density functional theory. The energy gap of free ligand is ?E?=?0.12565?eV, and this value is greater than energy gap of complexes, which indicates that the complexes are more reactive than free ligand. Also, ?E of Co(II) complex is lower than other complexes, which indicates that Co(II) complex is more reactive than Ni(II) and Cu(II) complexes. The antibacterial and antifungal activities of the ligand, metal salts and its complexes were tested against some microorganisms (bacteria and fungi). The complexes showed increased antibacterial and antifungal profile in comparison with the free ligand.

Spectroscopic, DFT and antimicrobial activity of Zn(II), Zr(IV), Ce(IV) and U(VI) complexes of N,N- chelated 4,6-bis (4-chlorophenyl)-2-amino-1,2-dihydropyridine-3-carbinitrile

Four novel metal complexes of 4,6-bis (4-chlorophenyl)-2-amino-1,2-dihydropyridine-3-carbinitrile (H2L) with Zn(II), Zr(IV), Ce(IV) and U(VI) were synthesized. The structure was elucidated using elemental analysis, melting point, molar conductivity; spectroscopic techniques (IR, 1H NMR, UV–Vis., mass spectra) as well as thermo gravimetric analysis. The spectroscopic data proved that H2L chelated with the metal ions as a bidentate ligand through Namino and Ncarbinitrile atoms. The molecular structure of the complexes was determined using density functional theory (DFT). The central metal ion in each complex is six-coordinate and the angles around it vary from 62.74° to 166.46°; these values agree with distorted octahedral geometry. The calculated total energy of the complexes found in the region – 406.342 to ?459.717 au and the dipole moment change from 4.675 to 13.171D. The antibacterial and antifungal activities of the ligand, metal salts and complexes were estimated on some microorganisms. The complexes showed significant antibacterial profile in comparison to the free ligand.

Synthesis, characterization, and application of CoFe2O4@TRIS@sulfated boric acid nanocatalyst for the synthesis of 2-amino-3-cyanopyridine derivatives

Abstract: The aim of this research is the synthesis of a novel acidic nanocatalyst using the layer-by-layer assembly technique. The CoFe2O4@TRIS@sulfated boric acid nanoparticles were easily synthesized and studied as a highly beneficial, recyclable, and magnetite nanocatalyst for the synthesis of 2-amino-3-cyanopyridine derivatives. The chemical structure of CoFe2O4@TRIS @sulfated boric acid nanocatalyst was completely confirmed with different techniques like FESEM, Map, EDS, XRD, TGA/DTG, VSM, and FT-IR analyses. Briefly, the newly synthesized nanocatalyst offers some advantages such as simplicity of work-up, highly stable, environmental friendliness, reusability, excellent yields, and short reaction time. Graphic abstract: [Figure not available: see fulltext.].

Synthesis of a novel acidic ionic liquid catalyst and its application for preparation of pyridines via a cooperative vinylogous anomeric-based oxidation

Abstract: In the current study, a novel acidic ionic liquid catalyst based on 8-hydroxyquinoline, namely 8,8′,8″-([1,3,5-triazine-2,4,6-triyl]tris[oxy])tris(1-sulfoquinolin-1-ium)chloride (TTS), was designed and synthesized. The structure of the prepared acidic ionic liquid (AIL) was fully investigated by using Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, thermogravimetric analysis/differential thermal analysis (TGA/DTA), 1HNMR, 13CNMR and mass spectroscopy. Then, the catalytic performance of described AIL was successfully inspected toward the four-component synthesis of pyridine derivatives via a cooperative vinylogous anomeric-based oxidation. Graphic abstract: Novel AIL (TTS) showed a very high efficiency in the synthesis of pyridines. [Figure not available: see fulltext.].

One-pot synthesis of 2-amino-3-cyanopyridines and hexahydroquinolines using eggshell-based nano-magnetic solid acid catalyst via anomeric-based oxidation

Abstract: In the present research, the eggshell as a hazardous waste by European Union regulations was converted to a valuable catalyst, namely nano-Fe3O4@(HSO4)2. The as-prepared catalyst, first, was characterized using different techniques, including Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). Back-titration method confirmed the loading of a high surface density of acidic group, namely 8.8?mmol HSO4 per gram of the catalyst. The catalytic property of the as-prepared catalyst was examined in the synthesis of 2-amino-3-cyanopyridines via anomeric-based oxidation (ABO), and hexahydroquinolines derivatives. High yield, short reaction time, solvent-free condition, waste to wealth, and optimization with the design of experiment are the major advantages of the present work. Taken together, these results suggest the conversion of waste to wealth products around the world and usage in organic transformation. Graphic abstract: [Figure not available: see fulltext.].

Synthesis of a novel and reusable biological urea based acidic nanomagnetic catalyst: Application for the synthesis of 2-amino-3-cyano pyridines via cooperative vinylogous anomeric based oxidation

In the current study, a novel and reusable biological urea based nano magnetic catalyst namely Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was designed and synthesized. The structure of the titled catalyst was fully characterized using several skills including Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo gravimetric analysis/differential thermal analysis (TG/DTG) and vibrating sample magnetometer (VSM). Then, the catalytic performance of Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was successfully inspected towards the multicomponent synthesis of 2-amino-3-cyano pyridine derivatives through a vinylogous anomeric based oxidation pathway.

Synthesis of a novel and reusable biological urea based acidic nanomagnetic catalyst: Application for the synthesis of 2-amino-3-cyano pyridines via cooperative vinylogous anomeric based oxidation

In the current study, a novel and reusable biological urea based nano magnetic catalyst namely Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was designed and synthesized. The structure of the titled catalyst was fully characterized using several skills including Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo gravimetric analysis/differential thermal analysis (TG/DTG) and vibrating sample magnetometer (VSM). Then, the catalytic performance of Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was successfully inspected towards the multicomponent synthesis of 2-amino-3-cyano pyridine derivatives through a vinylogous anomeric based oxidation pathway.

Novel magnetic nanoparticles with morpholine tags as multirole catalyst for synthesis of hexahydroquinolines and 2-amino-4,6-diphenylnicotinonitriles through vinylogous anomeric-based oxidation

A new heterogeneous nanomagnetic catalyst bearing morpholine tags was synthesized and characterized. The formation of the nanomagnetic catalyst was fully confirmed by several methods, including Fourier-transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetry/derivative thermogravimetry (TG/ DTG), and vibrating-sample magnetometry (VSM). The catalytic performance of the novel nanomagnetic catalyst was examined in multicomponent preparation of hexahydroquinolines and 2-amino-4,6-diphenylnicotinonitriles through vinylogous anomeric-based oxidation under mild reaction conditions.

Fe3O4@TiO2@O2PO2(CH2)NHSO3H as a novel nanomagnetic catalyst: Application to the preparation of 2-amino-4,6-diphenylnicotinonitriles via anomeric-based oxidation

A new, green and reusable nanomagnetic heterogeneous catalyst, namely Fe3O4@TiO2@O2PO2(CH2)NHSO3H, was synthesized and fully characterized using suitable techniques such as infrared spectroscopy, X-ray diffraction, scanning and transmission electron microscopies, thermogravimetry, vibrating sample magnetometry and energy-dispersive X-ray spectroscopy. The applicability of the constructed heterogeneous core–shell catalyst as a promoter was successfully explored for the synthesis of 2-amino-4,6-diphenylnicotinonitrile derivatives upon the reaction of a good range of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate. The desired products were obtained with good to high yields in short reaction times under solvent-free conditions. The suggested mechanism offers an anomeric-based oxidation route to the products in the final step of the synthetic pathway.

Highly efficient four-component synthesis of 2-amino-3-cyanopyridines using doped nano-sized copper(I) oxide (Cu2O) on melamine-formaldehyde resin

A convenient and facile four-component synthesis is described of 2-amino-3-cyanopyridine derivatives from readily available starting materials catalysed by doped nano-sized Cu2O on melamine-formaldehyde resin (nano-Cu2O-MFR). In this method, treatment of different aldehydes, ketones, malononitrile, and ammonium acetate in refluxing H2O/EtOH (1:1) in the presence of doped nano-Cu2O-MFR as a highly efficient heterogeneous catalyst affords the corresponding 2-amino-3-cyanopyridines in good to excellent yields. The nano-Cu2O-MFR is a cheap and stable nano-catalyst that could be easily recovered and reused for many consecutive reaction runs without considerable decrease in its activity.