1217-25-0

Basic information

• Product Name: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-phenyl-
• CAS NO: 1217-25-0
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• Mol File: 1217-25-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-phenyl-(1217-25-0)
• EPA Substance Registry System: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-phenyl-(1217-25-0)

Safety Data

• Hazardous Substances Data: 1217-25-0(Hazardous Substances Data)

Usage

General Description

2H-1,3-Benzoxazine-2,4(3H)-dione, 3-phenyl- is a chemical compound with the molecular formula C13H7NO3. It is also known as phthalimido-substituted benzoxazine, and is often used in the synthesis of various pharmaceuticals and agrochemicals. It is a white to light yellow crystalline powder with a melting point of 300-305°C. The compound has potential applications in the development of new drugs and has shown promising results in research studies related to its pharmacological properties. Additionally, it is also used in organic synthesis and as a building block in the production of various chemicals.

Upstream product

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• 108-23-6 isopropyl chloroformate 
• 88220-40-0 4--3-phenyl-2H-1,3-benzoxazin-2-one 
• 119-36-8 methyl salicylate 

Downstream Products

• 87-17-2 salicylanilide 
• 51756-54-8 morpholine-4-carboxylic acid N-(2-hydroxy-benzoyl)-anilide 

Relevant articles and documents

New application of triphosgene in a convenient synthesis of 3-aryl-1,3-benzoxazine-2,4-diones from anacardic acids

In conjunction with a search program focused on utilization of cashew (Anacardium occidentale) nut shell liquid (CNSL) as starting material for the preparation of useful compounds, a convenient synthesis of novel series of 3-aryl-1, 3-benzoxazine-2, 4-diones was prepared from anacardic acids by using of the triphosgene.

Multivariate regression with substituent shift increments. IV. 2-(4-X-phenyl)-1,3-dihydro-2H-isoindole-1,3-diones and 3-(4-X-phenyl)-3,4-dihydro-2H-1,3-benzoxazine-2,4-diones

Two series of para disubstituted benzenes were studied: 2-(4-X-phenyl)-1,3-dihydro-2H-isoindole-1,3-diones (1) and 3-(4-X-phenyl)-3,4-dihydro-2H-1,3-benzoxazine-2,4-diones (2). Their 1H and 13C chemical shifts were correlated with substituent shift increments (SSI) aj and zj, respectively. For 13C chemical shifts, all four zj values, zj, zo, zm, and zp, were used to check the assignment and to find out possible variables for improvement of regression equations. Significant deviations from plain additivity were observed in the case of δH3 and δC3 chemical shifts. This can be explained by changes in diamagnetic anisotropy contribution induced by different twist of 4-substituent from the benzene plane caused by variable substituent in position 1.

NEW GROUPS OF POTENTIAL ANTITUBERCULOTICS: 3-ARYL-2H,4H-BENZOXAZINE-2,4-DIONES. COMPARISON OF THE TOPLISS APPROACH WITH REGRESSION ANALYSIS

3-Phenyl-2H,4H-benzoxazine-2,4-dione (I) and its derivatives II - XI, substituted on the phenyl ring, can be regarded as a new group of potential antituberculotics.Their activity increases with increasing electron-accepting properties of the substituents.Introduction of bromine into the position 6 also positively influences the activity.The compounds are active in vitro against Mycobacterium tuberculosis and M. kansasii.The activity of some of them (VIII, IX) exceeds that of commercial tuberculostatics used as standards.