121701-93-7Relevant academic research and scientific papers
SYNTHESIS OF FRAGMENTS OF THE CAPSULAR POLYSACCHARIDE OF HAEMOPHILUS INFLUENZAE TYPE B, COMPRISING TWO OR THREE REPEATING UNITS
Hoogerhout, P.,Evenberg, D.,Boeckel, C. A. A. van,Poolman, J. T.,Beuvery, E. C.,et al.
, p. 1553 - 1556 (1987)
The synthesis of the ribosyl-ribitol derivatives 15 and 17 (Scheme 2) is presented.The compounds served as building blocks for the preparation of protected fragments (24, n=1 or 2; Fig. 2) of the title polysaccharide.The bifunctional reagent bis-2-chlorophenylphosphate (18, Fig. 2) was used for all phosphorylation reactions.Attachment to a spacer and complete deprotection of the products, to afford 25 (n=2 or 3), is described.
