SYNTHESIS OF FRAGMENTS OF THE CAPSULAR POLYSACCHARIDE OF HAEMOPHILUS INFLUENZAE TYPE B, COMPRISING TWO OR THREE REPEATING UNITS

Article abstract of DOI:10.1016/S0040-4039(01)81040-6

The synthesis of the ribosyl-ribitol derivatives 15 and 17 (Scheme 2) is presented.The compounds served as building blocks for the preparation of protected fragments (24, n=1 or 2; Fig. 2) of the title polysaccharide.The bifunctional reagent bis<1-benzotriazolyl>-2-chlorophenylphosphate (18, Fig. 2) was used for all phosphorylation reactions.Attachment to a spacer and complete deprotection of the products, to afford 25 (n=2 or 3), is described.