1217264-22-6Relevant articles and documents
Anti-cancer potential of novel glycosylated 1,4-substituted triazolylchalcone derivatives
Manna, Tapasi,Pal, Kunal,Jana, Kuladip,Misra, Anup Kumar
, (2019)
A series of glycosylated 1,4-substituted triazolyl chalcone derivatives (8a-f and 14a-r) were synthesized in high yield using 1,3-cycloaddition (Click chemistry) of D-glucosyl azides with a variety of propargylated chalcone derivatives followed by de-O-ac
Synthesis, Biological Evaluation and Molecular Modeling Studies of Propargyl-Containing 2,4,6-Trisubstituted Pyrimidine Derivatives as Potential Anti-Parkinson Agents
Kumar, Bhupinder,Kumar, Mohit,Dwivedi, Ashish Ranjan,Kumar, Vinod
, p. 705 - 712 (2018/03/21)
Monoamine oxidase B (MAO-B) inhibitors are potential drug candidates for the treatment of various neurological disorders including Parkinson's disease. A total of 20 new propargyl-containing 2,4,6-trisubstituted pyrimidine derivatives were synthesized and
Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents
Singh, Gurjaspreet,Arora, Aanchal,Mangat, Satinderpal Singh,Rani, Sunita,Kaur, Hargobinder,Goyal, Kapil,Sehgal, Rakesh,Maurya, Indresh Kumar,Tewari, Rupinder,Choquesillo-Lazarte, Duane,Sahoo, Subash,Kaur, Navneet
, p. 287 - 300 (2015/12/23)
A series of chalconyl blended triazole allied silatranes (7a-g/8a-g/9a-g) were synthesized in good yields using a simple, economical and biocompatible synthetic route. The blend of three different pharmacologically active moieties into a single scaffold r
Click reaction based synthesis, antimicrobial, and cytotoxic activities of new 1,2,3-triazoles
Syed Aly, Mohamed Ramadan El,Saad, Hosam Ali,Mohamed, Mosselhi Abdelnabi Mosselhi
supporting information, p. 2824 - 2830 (2015/06/08)
Three-motif pharmacophoric models 20a-e and 21-25 were prepared in good yields by CuAAC of two azido substrates 2 and 11 with seven terminal acetylenic derivatives including chalcones 17a-e, theophylline 18 and cholesterol 19. The structure of these compounds was elucidated by NMR, MS, IR spectroscopy and micro analyses. This series was screened as antimicrobial and cytotoxic agents in vitro. Most derivatives showed appreciable antibacterial activity, but they displayed weak cytotoxic, and antifungal activities. Notably, conjugate 25 (cream of the crop) was found to be more active than Ampicillin against Escherichia coli and Staphylococcus aureus and showed appreciable antifungal and cytotoxic activities as well.
Design, synthesis and anticancer activity of matrine-1H-1,2,3-triazole-chalcone conjugates
Zhao, Lihui,Mao, Lina,Hong, Ge,Yang, Xiaojiao,Liu, Tianjun
supporting information, p. 2540 - 2544 (2015/06/02)
Abstract A series of novel matrine-1H-1,2,3-triazole-chalcone conjugates was synthesized and their anticancer activity against A549, Bel-7402, Hela, and MCF-7 cancer cells was evaluated. Most of the conjugates displayed higher potency than their component
Synthetic investigations and photo-physical properties of 1,2,3-triazole encapped chalconyl substituted organotriethoxysilanes
Singh, Gurjaspreet,Arora, Aanchal,Mangat, Satinderpal Singh,Singh, Jandeep,Rani, Sunita,Kaur, Navneet
, p. 6 - 15 (2015/01/09)
Organotriethoxysilanes (OTES) play an impressive role in the designing of organic-inorganic hybrid materials. The highly efficient copper catalysed 'Click Silylation' is followed for the functionalization of 3-azidopropyltriethoxysilane (AzPTES) with a se