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34264-14-7

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34264-14-7 Usage

General Description

1-[4-(2-propynyloxy)phenyl]-1-ethanone is a chemical compound with the molecular formula C13H12O2. It is a ketone compound, which means it contains a carbonyl group bonded to two carbon atoms. The structure of this compound consists of a phenyl ring with a propynyloxy group attached to it, and a ketone group attached to the adjacent carbon atom. It is used in various industrial and research applications, including as a building block in organic synthesis and as a reagent in chemical reactions. Additionally, it may have potential pharmaceutical or biological applications due to its unique structure and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 34264-14-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,2,6 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 34264-14:
(7*3)+(6*4)+(5*2)+(4*6)+(3*4)+(2*1)+(1*4)=97
97 % 10 = 7
So 34264-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H10O2/c1-3-8-13-11-6-4-10(5-7-11)9(2)12/h1,4-7H,8H2,2H3

34264-14-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-prop-2-ynoxyphenyl)ethanone

1.2 Other means of identification

Product number -
Other names 1-[4-(prop-2-yn-1-yloxy)phenyl]ethan-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34264-14-7 SDS

34264-14-7Relevant articles and documents

Synthesis and X-ray structural investigation of 1,3,5-trisbenzene

Lindeman, S. V.,Dvorikova, R. A.,Gol'din, I. R.,Struchkov, Yu. T.,Teplyakov, M. M.

, p. 1536 - 1539 (1993)

Synthesis and X-ray structural investigation of 1,3,5-trisbenzene (1) were carried out.Compound 1 is a trifunctional monomer for the synthesis of crosslinked polymers and a model of a section of polymeric network of this kind.In a

Bis-Organosilicon based receptor for detection of Hg2+ ions: Low detection limit and excellent selectivity

Chowdhary, Kavita,Mohit,Satija, Pinky,Sharma, Geetika,Shilpy,Singh, Akshpreet,Singh, Gurjaspreet,Singh, Jandeep,Singh, Jasbhinder

, (2020)

Mercury Contamination represents a major environmental and health concern for which new eco-friendly solutions are desired. Azide–alkyne cycloaddition and Claisen Schmidt reaction were attempted to trigger a flavanone based bis-siloxyl hybrid materials. T

Peroxide- And transition metal-free electrochemical synthesis of α,β-epoxy ketones

Zhang, Mengxun,Chen, Tie,Fang, Shisong,Wu, Weihua,Wang, Xin,Wu, Haiqiang,Xiong, Yongai,Song, Jun,Li, Chenyang,He, Zhendan,Lee, Chi-Sing

supporting information, p. 2481 - 2486 (2021/04/02)

A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors**

Anantharajan, Jothi,Baburajendran, Nithya,Foo, Klement,Joy, Joma K.,Keller, Thomas H.,Kwek, Perlyn Z.,Li, Rong,Liu, Boping,Poulsen, Anders,Quach, David,Retna, Priya,Tang, Guanghui,Tee, Doris H. Y.,Wee, John L. K.,Yang, Wan-Qi,Yao, Shao Q.,Zhang, Chong-Jing

supporting information, p. 17131 - 17137 (2021/06/28)

Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid (CBA) warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent targeting of the catalytic lysine with improved potency against both wild-type and mutant ABL kinases, especially ABLT315I bearing the gatekeeper residue mutation. We show the evolutionarily conserved lysine can be targeted selectively, and the selectivity depends largely on molecular recognition of the non-covalent pharmacophore in this class of inhibitors, probably due to the moderate reactivity of the warhead. We report the first co-crystal structures of covalent inhibitor-ABL kinase domain complexes, providing insights into the interaction of this warhead with the catalytic lysine. We also employed label-free mass spectrometry to evaluate off-targets of our compounds at proteome-wide level in different mammalian cells.

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