34264-14-7

Usage

Uses

Used in Organic Synthesis:
1-[4-(2-PROPYNYLOXY)PHENYL]-1-ETHANONE is used as a building block in organic synthesis for its ability to contribute to the formation of complex organic molecules. Its unique structure allows for versatile reactions and the creation of a wide range of compounds.
Used in Chemical Reactions:
As a reagent, 1-[4-(2-PROPYNYLOXY)PHENYL]-1-ETHANONE is utilized in various chemical reactions to facilitate the synthesis of desired products. Its ketone and propynyloxy functionalities make it a valuable component in the preparation of different chemical entities.
Used in Pharmaceutical Research:
1-[4-(2-PROPYNYLOXY)PHENYL]-1-ETHANONE may have potential pharmaceutical applications due to its distinctive structure and properties. It could be explored for its possible interactions with biological targets, serving as a lead compound in drug discovery processes.
Used in Biological Research:
1-[4-(2-PROPYNYLOXY)PHENYL]-1-ETHANONE's unique structure also suggests potential uses in biological research, where it might be employed to study its interactions with biological systems or to develop new probes for understanding cellular processes.

InChI:InChI=1/C11H10O2/c1-3-8-13-11-6-4-10(5-7-11)9(2)12/h1,4-7H,8H2,2H3

Upstream product

• 106-96-7 propargyl bromide 
• 99-93-4 4-Hydroxyacetophenone 
• 6165-76-0 propargyl p-toluenesulfonate 
• 122-79-2 Phenyl acetate 
• 108-95-2 phenol 

Downstream Products

• 99-93-4 4-Hydroxyacetophenone 
• 879216-14-5 5-(4-prop-2-ynyloxy-phenyl)-isoxazole-3-carboxylic acid methyl ester 
• 879216-22-5 5-(4-prop-2-ynyloxy-phenyl)-isoxazole-3-carboxylic acid 
• 1144040-27-6 1-(4-{1-[2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl]-1H-[1,2,3]triazol-4-ylmethoxy}-phenyl)-ethanone 
• 1161299-19-9 C₁₇H₂₃O₅P 
• 1227420-57-6 3-(4-methoxy-phenyl)-1-(4-prop-2-ynyloxy-phenyl)-propenone 
• 1227420-58-7 3-(2,4-dimethoxy-phenyl)-1-(4-prop-2-ynyloxy-phenyl)-propenone 
• 1227420-59-8 1-(4-prop-2-ynyloxy-phenyl)-3-(2,3,4-trimethoxy-phenyl)-propenone 
• 1225219-28-2 2-(furan-2-yl)-2-[4-(4-acetylphenoxymethyl)-1H-1,2,3-triazol-1-yl]ethanol 

Relevant academic research and scientific papers

Synthesis and X-ray structural investigation of 1,3,5-trisbenzene

Synthesis and X-ray structural investigation of 1,3,5-trisbenzene (1) were carried out.Compound 1 is a trifunctional monomer for the synthesis of crosslinked polymers and a model of a section of polymeric network of this kind.In a

Novel 1,2,3-triazolo phosphonate derivatives as potential antibacterial agents

We describe the synthesis, characterization, and in vitro antibacterial evaluation of a library of novel compounds based on 1,2,3-triazolo phosphonate framework along with the evaluation of DNA gyrase inhibitory potential of a promising molecule in silico

Bis-Organosilicon based receptor for detection of Hg2+ ions: Low detection limit and excellent selectivity

Mercury Contamination represents a major environmental and health concern for which new eco-friendly solutions are desired. Azide–alkyne cycloaddition and Claisen Schmidt reaction were attempted to trigger a flavanone based bis-siloxyl hybrid materials. T

Peroxide- And transition metal-free electrochemical synthesis of α,β-epoxy ketones

A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.

Development of pH-activatable fluorescent probes for rapid visualization of metastatic tumours and fluorescence-guided surgeryviatopical spraying

A series of pH-activatable aza-BODIPY-based fluorescent probes were developed for rapid cancer visualization and real-time fluorescence-guided surgery by harnessing topical spraying. These probes exhibited good water-solubility, a tunable pKafrom 5.0 to 7.9, and stable intense NIR emission at ～725 nm under acidic conditions.AzaB5with a pKavalue of 6.7 was able to rapidly and clearly visualize pulmonary and abdominal metastatic tumours including tiny metastases less than 2 mmviatopical spraying, further improving intraoperative fluorescence-guided resection. We believe thatAzaB5is promising as a powerful tool to rapidly delineate a broad range of malignancies and assist surgical tumour resection.

Preparation method and application of propyne aryl ether compound

The invention particularly relates to a method for preparing propyne aryl ether compounds from aryl phenol, halogenated propyne and derivatives of the halogenated propyne, and belongs to the technical field of preparation of the propyne aryl ether compoun

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors**

Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid (CBA) warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent targeting of the catalytic lysine with improved potency against both wild-type and mutant ABL kinases, especially ABLT315I bearing the gatekeeper residue mutation. We show the evolutionarily conserved lysine can be targeted selectively, and the selectivity depends largely on molecular recognition of the non-covalent pharmacophore in this class of inhibitors, probably due to the moderate reactivity of the warhead. We report the first co-crystal structures of covalent inhibitor-ABL kinase domain complexes, providing insights into the interaction of this warhead with the catalytic lysine. We also employed label-free mass spectrometry to evaluate off-targets of our compounds at proteome-wide level in different mammalian cells.

Molecular docking studies on COVID-19 and antibacterial evaluation of newly synthesized 4-(methoxymethyl)-1,2,3-triazolean analogues derived from (E)-1-phenyl-3-(2-(piperidin-1-yl)quinolin-3-yl) prop-2-en-1-one

A series of novel quinolone-based 4-(methoxymethyl)-1,2,3-triazole derivatives were synthesized, and their structures were characterized by 1H, 13C NMR and mass spectroscopy. The compounds (IXa-l) were screened in vitro antibacterial

Functionalized organosilanes and their magnetic nanoparticles as receptor for Sn (II) ions detection and potent antioxidants

In this article, we proposed the synthesis of chalcone derived organosilanes based on polycyclic aromatic compounds. All the synthesized compounds were well categorized using numerous spectroscopic techniques such as IR, NMR (1H and 13/su

Self-assembled star-shaped aza-BODIPY mesogen affords white-light emission

A novel multifunctional star-shaped aza-BODIPY mesogen was synthesized by a click reaction. This star-shaped aza-BODIPY mesogen undergoes self-assembly into a hexagonal columnar phase in its bulk state and spherical gels in organic solvents. Based on the