121749-58-4

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 60-29-7 diethyl ether 
• 344-00-3 ethyl 2-methyl-4,4,4-trifluoroacetoacetate 

Downstream Products

• 1233840-52-2 3-[5-hydroxy-4-(4-methoxybenzyl)-3-trifluromethylpyrazol-1-yl]-propionitrile 
• 1233840-29-3 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-ol 
• 1233840-35-1 1-benzyl-4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-ol 
• 1233840-37-3 [3-hydroxy-4-(4-methoxy-benzyl)-5-trifluoromethyl-pyrazol-1-yl]-phenyl-methanone 
• 152595-64-7 4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-ol 
• 117896-99-8 1,1,1-trifluoro-4-(4-hydroxyphenyl)-2-butanone 

Relevant academic research and scientific papers

INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF FLUOROGLYCOSIDE DERIVATIVES

The present invention provides processes for producing (2S,3R,4R,5S,6R)-5-fluoro-6- hydroxymethyl-2-[4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]- tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof, of high purity and in a relatively

Nonpeptide endothelin antagonists: From lower affinity pyrazol-5-ols to higher affinity pyrazole-5-carboxylic acids

Random screening of compounds in endothelin receptor (ET(A) and ET(B)) binding assays led to the discovery of a new class of pyrazol-5-ol ligands. Characterization of structural features crucial for binding activities of these pyrazol-5-ols, by structure-activity-relationship (SAR) studies, allowed us to design a novel class of pyrazole-5-carboxylic acids as more potent ET antagonists. (C) 2000 Elsevier Science Ltd. All rights reserved.

Fluoroketone enzyme inhibitors

A method for enzyme immunoassay for a ligand suspected to be present in a liquid sample includes signal amplification by use of at least two enzymes and a blocked modulator for one of the enzymes. Ligand present in the liquid binds to an antiligand and an