1217510-14-9

Basic information

• Product Name: (4S)-2-(2,6-Dichlorophenyl)-1,3-thiazolidine-4-carboxylic acid
• Synonyms: (4S)-2-(2,6-Dichlorophenyl)-1,3-thiazolidine-4-carboxylic acid
• CAS NO: 1217510-14-9
• Molecular Formula: C10H9Cl2NO2S
• Molecular Weight: 278.15496
• Mol File: 1217510-14-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4S)-2-(2,6-Dichlorophenyl)-1,3-thiazolidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-2-(2,6-Dichlorophenyl)-1,3-thiazolidine-4-carboxylic acid(1217510-14-9)
• EPA Substance Registry System: (4S)-2-(2,6-Dichlorophenyl)-1,3-thiazolidine-4-carboxylic acid(1217510-14-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1217510-14-9(Hazardous Substances Data)

Usage

General Description

(4S)-2-(2,6-Dichlorophenyl)-1,3-thiazolidine-4-carboxylic acid is a chemical compound with potential pharmaceutical applications. Its structure contains a thiazolidine ring and a carboxylic acid group, making it a potential candidate for drug development. The presence of the dichlorophenyl group suggests that the compound may have selective interactions with specific biological targets, making it a potential candidate for the development of new therapeutic agents. Further research and studies are needed to fully understand the potential uses and properties of this compound.

Upstream product

• 52-90-4 L-Cysteine 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 52-89-1 l-cysteine hydrochloride 

Relevant articles and documents

X-ray crystal structures and anti-breast cancer property of 3-tert -butoxycarbonyl-2-arylthiazolidine-4-carboxylic acids

Diastereomeric '2RS,4R'-2-arylthiazolidine-4-carboxylic acids (ATCAs) were synthesized and their resolution to chiraly pure N-BOC derivatives was attempted by column chromatography. The absolute stereochemistry of the resolved compounds was ascertained by X-ray single crystal structures. Further application of the synthesized compounds was studied for their in vitro anti-breast cancer activity against MCF7 cell line using DOX as a standard by MTT assay method. Cell morphology analysis was carried out by fluorescence microscopy. The compounds containing '2S' absolute configuration in thiazolidine ring and presence of 2-NO2, 2,6-Cl groups on '2R'-aryl substituent showed significant anti-breast cancer activity where some of the compounds were found to be more active than DOX in terms of induced apoptosis mode of MCF7 cell death.

Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies

The present study describes the synthesis of a series of new 4-aminoquinoline-derived thiazolidines and evaluation of their antimalarial activity against a NF-54 strain of Plasmodium falciparum in vitro and N-67 strain of Plasmodium yoelii in vivo. Among the series, two compounds, 2-(4-chloro-phenyl)-thiazolidine-4-carboxylic acid [2-(7-chloro-quinolin-4- ylamino)-ethyl]-amide hydrochloride (14) and 2-(2,6-dichloro-phenyl)- thiazolidine-4-carboxylic acid [2-(7-chloro-quinolin-4-ylamino)-ethyl]-amide hydrochloride (22) exhibited significant suppression of parasitaemia in the in vivo assay. All the analogues were found to form strong complex with haematin and inhibited the β-haematin formation in vitro. These results suggest that these compounds act on heme polymerization target.