1217603-41-2

Usage

Uses

Used in Pharmaceutical Development:
FMoc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid is utilized as a key component in the synthesis of complex peptides and proteins for pharmaceutical applications. Its role is crucial for the development of new drugs and therapeutic agents.
Used in Biochemical Research:
In the field of biochemical research, FMoc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid serves as a valuable tool for the study of peptide and protein structures, functions, and interactions.
Used in Biotechnological Applications:
FMoc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid is employed in biotechnological research and applications, where it aids in the production and modification of bioactive peptides and proteins for various uses, including diagnostics, therapeutics, and industrial processes.
Used in Solid-Phase Peptide Synthesis:
FMoc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid is used as a building block in solid-phase peptide synthesis, a technique that allows for the stepwise assembly of peptides in a controlled and efficient manner. Its stability and protective properties are essential for the successful synthesis of complex peptide sequences.

Upstream product

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Relevant academic research and scientific papers

Gold-Catalyzed Amide/Carbamate-Linked N, O-Acetal Formation with Bulky Amides and Alcohols

A gold-catalyzed N,O-acetal formation was established to construct an amide/carbamate-linked N,O-acetal substructure with bulky alcohols. The acyliminium cation species generated from o-alkynylbenzoic acid ester in the presence of a gold catalyst is highly reactive and underwent nucleophilic attack of various bulky alcohols and phenols at room temperature under neutral conditions, leading to the corresponding N,O-acetals in yields of 34-89% with good functional group tolerance.

COMPOUNDS USEFUL FOR TREATING A MANNHEIMIA HAEMOLYTICA OR HISTOPHILUS SOMNI INFECTION

The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

COMPOUNDS FOR THE TREATMENT OF BOVINE OR SWINE RESPIRATORY DISEASE

The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

Total synthesis of the large non-ribosomal peptide polytheonamide B

Polytheonamide B is by far the largest non-ribosomal peptide known at present, and displays extraordinary cytotoxicity (EC50 =68 pg ml -1 , mouse leukaemia P388 cells). Its 48 amino-acid residues include a variety of non-proteinogenic d- and l-amino acids, and the absolute stereochemistry of these amino acids alternate in sequence. These structural features induce the formation of a stable β-strand-type structure, giving rise to an overall tubular structure over 30A? in length. In a biological setting, this fold is believed to transport cations across the lipid bilayer through a pore, thereby acting as an ion channel. Here, we report the first chemical construction of polytheonamide B. Our synthesis relies on the combination of four key stages: syntheses of non-proteinogenic amino acids, a solid-phase assembly of four fragments of polytheonamide B, silver-mediated connection of the fragments and, finally, global deprotection. The synthetic material now available will allow studies of the relationships between its conformational properties, channel functions and cytotoxicity.