121767-80-4Relevant academic research and scientific papers
ENDOTHELIN RECEPTOR ANTAGONISTS
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Page column 20, (2008/06/13)
Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
ENDOTHELIN RECEPTOR ANTAGONISTS
-
, (2008/06/13)
Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
Relevance of Conformational Constraints to the Regioselective Lithiation of Aromatic Diethers. Application to the Convenient Construction of the DEF Tricyclic Subunit of the Austalides
Paquette, Leo A.,Schulze, Matthias M.,Bolin, David G.
, p. 2043 - 2051 (2007/10/02)
The lithiation of 29 and 30 is shown to occur at all three sites with a dissimilar kinetic preference.For the dihydrofuran, reaction at the proton labeled Hβ' operates predominantly; in the dihydropyran example, Hα is the favored sit
The Synthesis of 5-Substituted 2,3-Dihydrobenzofurans
Alabaster, Ramon J.,Cottrell, Ian F.,Marley, Hugh,Wright, Stanley H. B.
, p. 950 - 952 (2007/10/02)
The preparation of 2,3-dihydrobenzofurans 6 from 2-(2-bromophenoxy)ethyl chlorides 3 by reaction with magnesium in a development of the Parham cyclialkylation reaction is described.A high yielding procedure using phase-transfer catalysis has also been developed for the preparation of the intermediate chloroethyl ethers 3 from bromophenols 2.The 5-hydroxy derivative 15 may be obtained from 2,3-dihydrobenzofuran (6a) by reaction with electrophilic reagents followed by oxidation.
