99355-75-6Relevant academic research and scientific papers
ENDOTHELIN RECEPTOR ANTAGONISTS
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Page column 21, (2008/06/13)
Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
A practical approach to highly functionalized benzodihydrofurans
Plotkin, Michael,Chen, Sanyou,Spoors, P. Grant
, p. 2269 - 2273 (2007/10/03)
A number of aromatic dibromides have been treated with 2-3 equivalents of n-butyllithium in order to initiate two sequential chemical events, a Parham cyclization and an intermolecular reaction with DMF. (C) 2000 Elsevier Science Ltd.
ENDOTHELIN RECEPTOR ANTAGONISTS
-
, (2008/06/13)
Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
Relevance of Conformational Constraints to the Regioselective Lithiation of Aromatic Diethers. Application to the Convenient Construction of the DEF Tricyclic Subunit of the Austalides
Paquette, Leo A.,Schulze, Matthias M.,Bolin, David G.
, p. 2043 - 2051 (2007/10/02)
The lithiation of 29 and 30 is shown to occur at all three sites with a dissimilar kinetic preference.For the dihydrofuran, reaction at the proton labeled Hβ' operates predominantly; in the dihydropyran example, Hα is the favored sit
Antioxidant-Based Inhibitors of Leukotriene Biosynthesis. The Discovery of 6--1-propen-3-yl>-2,3-dihydro-5-benzofuranol, a Potent Topical Antiinflammatory Agent
Hammond, Milton L.,Zambias, Robert A.,Chang, Michael N.,Jensen, Norman P.,McDonald, John,et al.
, p. 909 - 918 (2007/10/02)
The leukotrienes, metabolites of arachidonic acid produced through the action of the enzyme 5-lipoxygenase, are important mediators of immediate hypersensitivity and inflammation.Among the variety of diseases in which the leukotrienes may play a symptomat
Synthesis and Evaluation of 2,3-Dihydrobenzofuran Analogues of the Hallucinogen 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane: Drug Discrimination Studies in Rats
Nichols, David E.,Hoffman, Andrew J.,Oberlender, Robert A.,Riggs, Robert M.
, p. 302 - 304 (2007/10/02)
Two analogues, 6-(2-aminopropyl)-5-methoxy-2,3-dihydrobenzofuran and 6-(2-aminopropyl)-5-methoxy-2-methyl-2,3-dihydrobenzofuran, of the hallucinogenic agent 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) were synthesized and tested in the two-lever drug discrimination paradigm.In rats trained to discriminate saline from LSD tartrate (0.08 mg/kg), stimulus generalization occurred to both of the 2,3-dihydrobenzofuran analogues but at doses more than 10-fold higher than for DOM.A possible explanation for this dramatic attenuation of LSD-like activity could involve a highly directional electrophilic binding site on the receptor that cannot accept the orientation of the unshared electron pairs on the heterocyclic oxygen atom in the benzofurans.
Substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof useful as anti-inflammatory agents
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, (2008/06/13)
Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted (5-hydroxy-2,3-dihydrobenzofuran-6-yl) formaldehyde or analog thereof with an aryl amine follo
