121767-86-0

Upstream product

• 121767-81-5 4-Benzyloxy-2-bromo-1-(2-chloro-ethoxy)-benzene 
• 177259-98-2 2-[(3-(benzyloxy)phenyl)]ethan-1-ol 
• 13398-94-2 2-(3-hydroxyphenyl)ethanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 126080-75-9 2-[(E)-3-(5-Benzyloxy-2,3-dihydro-benzofuran-6-yl)-propenyl]-benzoic acid methyl ester 
• 126080-76-0 2-[(E)-3-(5-Benzyloxy-2,3-dihydro-benzofuran-6-yl)-propenyl]-benzonitrile 
• 126080-74-8 5-Benzyloxy-6-[(E)-3-(2-bromo-phenyl)-allyl]-2,3-dihydro-benzofuran 
• 126080-66-8 5-Benzyloxy-6-bromo-2,3-dihydrobenzofuran 

Relevant academic research and scientific papers

Synthesis of Functionalized Dihydrobenzofurans by Direct Aryl C?O Bond Formation under Mild Conditions

A method for the synthesis of dihydrobenzofurans by a direct aryl C?O bond formation is described. A mechanistic pathway for the reaction, distinct from previously described similar transformations, allows for mild reaction conditions that are expected to be compatible with functionalized substrates.

The Synthesis of 5-Substituted 2,3-Dihydrobenzofurans

The preparation of 2,3-dihydrobenzofurans 6 from 2-(2-bromophenoxy)ethyl chlorides 3 by reaction with magnesium in a development of the Parham cyclialkylation reaction is described.A high yielding procedure using phase-transfer catalysis has also been developed for the preparation of the intermediate chloroethyl ethers 3 from bromophenols 2.The 5-hydroxy derivative 15 may be obtained from 2,3-dihydrobenzofuran (6a) by reaction with electrophilic reagents followed by oxidation.