1217710-80-9

Basic information

• Product Name: 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester
• Synonyms: 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester;tert-butyl 3-{[(tert-butoxy)carbonyl]aMino}piperidine-1-carboxylate;(S)-1-BOC-3-N-BOC-AMINO-PIPERIDINE
• CAS NO: 1217710-80-9
• Molecular Formula: C15H28N2O4
• Molecular Weight: 300.39382
• Mol File: 1217710-80-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 397.5±31.0 °C(Predicted)
• Appearance: /
• Density: 1.07
• Storage Temp.: 2-8°C
• PKA: 12.26±0.20(Predicted)
• CAS DataBase Reference: 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester(1217710-80-9)
• EPA Substance Registry System: 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester(1217710-80-9)

Safety Data

• Hazardous Substances Data: 1217710-80-9(Hazardous Substances Data)

Usage

Uses

tert-Butyl 3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate, is a building block used in chemical synthesis.

InChI:InChI=1S/C15H28N2O4/c1-14(2,3)20-12(18)16-11-8-7-9-17(10-11)13(19)21-15(4,5)6/h11H,7-10H2,1-6H3,(H,16,18)

Upstream product

• 127294-73-9 (R)-piperidin-3-ylamine 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Nucleophile-dependent regio- and stereoselective ring opening of 1-azoniabicyclo[3.1.0]hexane tosylate

1-[(1R)-(1-Phenylethyl)]-1-azoniabicyclo[3.1.0]hexane tosylate was generated as a stable bicyclic aziridinium salt from the corresponding 2-(3-hydroxypropyl)aziridine upon reaction with p-toluenesulfonyl anhydride. This bicyclic aziridinium ion was then treated with various nucleophiles including halides, azide, acetate, and cyanide in CH3CN to afford either piperidines or pyrrolidines through regio- and stereoselective ring opening, mediated by the characteristics of the applied nucleophile. On the basis of DFT calculations, ring-opening reactions under thermodynamic control yield piperidines, whereas reactions under kinetic control can yield both piperidines and pyrrolidines depending on the activation energies for both pathways. A ring thing: 1-[(1R)-(1-Phenylethyl)]-1-azoniabicyclo[3.1.0]hexane tosylate generated from 2-(3-hydroxypropyl)aziridine with p-toluenesulfonyl anhydride was treated with various nucleophiles including halide, azide, acetate, and cyanide in CH3CN to afford either piperidines or pyrrolidines through regio- and stereoselective ring opening (see scheme).