127294-73-9

Basic information

• Product Name: (R)-3-Aminopiperidine
• Synonyms: (R)-3-AMINOPIPERIDINE;3-PiperidinaMine, (3R)-;(R)-piperidin-3-ylaMine.2HCl;(3R)-piperidin-3-amine;(3R)-3-Piperidinamine
• CAS NO: 127294-73-9
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.16
• EINECS: 1312995-182-4
• Product Categories: Chiral chemicals
• Mol File: 127294-73-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 157.9 °C at 760 mmHg
• Flash Point: 52.7 °C
• Appearance: /
• Density: 0.91g/cm³
• Vapor Pressure: 2.69mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.49±0.20(Predicted)
• CAS DataBase Reference: (R)-3-Aminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Aminopiperidine(127294-73-9)
• EPA Substance Registry System: (R)-3-Aminopiperidine(127294-73-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 127294-73-9(Hazardous Substances Data)

Usage

General Description

"(R)-3-Aminopiperidine is an organic compound that falls into the category of piperidines, which are heterocyclic organic compounds with the molecular formula (CH2)5NH. As an enantiomer, it comes in two forms: the 'R' (right-handed) and 'S' (left-handed) versions, distinguished by their different structures and properties. This chemical has diverse applications, particularly in the field of pharmaceuticals, where it serves as an integral part of several drug structures due to its ability to interact with biological molecules. It is crucial to handle and store it properly due to its potentially harmful nature.

InChI:InChI=1/C5H12N2/c6-5-2-1-3-7-4-5/h5,7H,1-4,6H2/t5-/m1/s1

Upstream product

• 42538-31-8 (3S)-3-aminopiperidin-2-one hydrochloride 
• 16682-12-5 D-ornithine hydrochloride 
• 94695-52-0 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid 
• 462-08-8 pyridin-3-ylamine 
• 54012-73-6 3-aminopiperidine 
• 40216-82-8 methyl (S)-2,5-diaminopentanoate dihydrochloride 
• 3184-13-2 L-ornithine hydrochloride 
• 34294-79-6 (S)-(-)-3-aminopiperidin-2-one 
• 2530-26-9 3-nitropyridine 
• 4318-76-7 pyridine-2,5-diamine 
• 64-17-5 ethanol 

Downstream Products

• 334618-87-0 ethyl 4-{(3S)-aminopiperidin-1-yl}benzoate 
• 334618-74-5 4-{(3S)-aminopiperidin-1-yl}benzonitrile 
• 334618-09-6 methyl 4-{(3S)-aminopiperidin-1-yl}-3-fluorobenzoate 
• 879009-95-7 methyl 4-{(3S)-aminopiperidin-1-yl}-3-chlorobenzoate 
• 334619-11-3 ethyl 4-{(3S)-aminopiperidin-1-yl}-2-chlorobenzoate 
• 879009-99-1 methyl 4-{(3S)-aminopiperidin-1-yl}-2,3-difluorobenzoate 
• 334619-46-4 ethyl 4-{(3S)-aminopiperidin-1-yl}-2-trifluoromethylbenzoate 
• 334618-97-2 ethyl 4-{(3S)-aminopiperidin-1-yl}-2-fluorobenzoate 
• 54012-73-6 (S)-piperidin-3-amine 
• 1638544-64-5 Alogliptin benzoate 
• 850649-61-5 alogliptin 
• 1029644-06-1 1-[2-(4-fluorophenyl)ethyl]piperidine-3-amine 

Relevant articles and documents

Reactions of Copper(II) Complexes of Optically Active N-Substituted Diamines with Alk-3-en-2-ones or 4-Hydroxyalkan-2-ones: Formation of Optically Active Macrocycles

The reaction of biscopper(II) with but-3-en-2-one in methanol in the presence of ammonia gives an optically active tetra-azamacrocyclic comlex in ca. 80percent yield.Analogous optically active complexes are also obtained from biscopper(II) or biscopper(II) by the same procedure.The introduction of methyl and/or a hydroxyl group at the C4 position of but-3-en-2-one leads to a decrease in the reactivity of the ketones, and changes the species and distribution of the reaction products.In particular, when the C4 position is fully substituted with methyl groups, C-N bond formation with the secondary amino group no longer proceeds.The change in the reaction mode due to the substituents at C4 is discussed.

One-pot synthesis of cyclohexylamine and: N -aryl pyrroles via hydrogenation of nitroarenes over the Pd0.5Ru0.5-PVP catalyst

The direct synthesis of cyclohexylamine via the hydrogenation of nitrobenzene over monometallic (Pd, Ru or Rh) and bimetallic (PdxRu1-x) catalysts was studied. The Pd0.5Ru0.5-PVP catalyst was the most effective catalyst for this reaction. The catalyst can be reused and applied for the synthesis of N-aryl pyrroles and quinoxalines from nitrobenzenes.

Novel chiral derivatizing agents for 1H NMR determination of enantiomeric purities of carboxylic acids

(S)-4-(3-Aminopyrrolidin-1-yl)coumarin (1), (S)-4-(3-aminopiperidin-1-yl)coumarin (4), and (S)-4-(3-aminoazepan-1-yl)coumarin (7), prepared from 4-chlorocoumarin and (S)-pyrrolidin-3-amine, (S)-piperidin-3-amine, and (S)-azepan-3-amine, respectively, were proven to be versatile and reliable 1H NMR optical purity determination agents for chiral carboxylic acids.