1217779-98-0

Basic information

• Product Name: (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL
• Synonyms: (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL;(R)-g-(3-Fluorobenzyl)-L-proline·HCl;(2S,4R)-4-(3-FLUOROBENZYL)PYRROLIDINE-2-CARBOXYLICACIDHCL
• CAS NO: 1217779-98-0
• Molecular Formula: C12H15ClFNO2
• Molecular Weight: 259.7
• Mol File: 1217779-98-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL(1217779-98-0)
• EPA Substance Registry System: (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL(1217779-98-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 1217779-98-0(Hazardous Substances Data)

Usage

Description

(R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL is a chemical compound that belongs to the class of proline derivatives. It is an enantiomer of the naturally occurring amino acid proline and contains a 3-fluoro-benzyl group. (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL is commonly used in the synthesis and development of pharmaceuticals and serves as a building block in organic chemistry. The hydrochloride salt form of this compound is often utilized for better solubility and stability in aqueous solutions. It is an important intermediate for the preparation of various drugs and may have potential therapeutic applications.

Uses

Used in Pharmaceutical Synthesis:
(R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and properties make it a valuable building block in the development of new medications.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL is used as a versatile building block for the creation of complex organic molecules. Its 3-fluoro-benzyl group and proline derivative nature contribute to its utility in organic synthesis.
Used in Drug Development:
(R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL is used as a potential therapeutic agent in drug development. Its unique structure may offer new avenues for the treatment of various diseases and conditions, making it a promising candidate for further research and development.
Used in Solubility and Stability Enhancement:
The hydrochloride salt form of (R)-GAMMA-(3-FLUORO-BENZYL)-L-PROLINE-HCL is used to improve the solubility and stability of the compound in aqueous solutions. This enhancement is crucial for the compound's application in pharmaceutical formulations and drug delivery systems.

Upstream product

• 256487-77-1 (R)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 3398-22-9 trans-4-hydroxyproline 
• 178962-09-9 methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate 
• 135042-17-0 (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 102195-80-2 (S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 686766-59-6 4-(3-fluoro-benzylidene)-pyrrolidine-1,2-dicarboxylic acid-1-tert butyl ester 2-methyl ester 
• 866488-98-4 4-(3-fluoro-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(2-isopropyl-5-methyl-cyclohexyl)ester 
• 866489-00-1 (2S)-4-(3-fluoro-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 686766-74-5 4-(3-fluoro-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(2-isopropyl-5-methyl-cyclohexyl) ester 

Relevant articles and documents

Part 3: Design and synthesis of proline-derived α2δ ligands

A potent series of substituted (2S,4S)-benzylproline α 2δ ligands have been designed from the readily available starting material (2S,4R)-hydroxy-l-proline. The ligands have improved pharmacokinetic profile over the (4S)-phenoxyproline derivati

PROLINE DERIVATIVES HAVING AFFINITY FOR THE CALCIUM CHANNEL ALPHA-2-DELTA SUBUNIT

The compounds of formula (I) or a pharmaceutically acceptable salt, solvate or pro-drug thereof, are proline derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, fibromyalgia, arthritis, neuropathalogical disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included. Wherein either X is O, S, NH or CH2 and Y is CH2 or a direct bond, or Y is O, S or NH and X is CH2; and R is a 3-12 membered cycloalkyl, 4-12 membered heterocycloalkyl, heteroaryl or aryl, where any ring may be optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, nitro, amino, hydroxycarbonyl, Cl-C6 alkyl, Cl-C6 alkenyl, CI-C6 alkynyl, Cl-C6 alkoxy, hydroxyC,-C6 alkyl, Cl-C6 alkoxyC,-C6 alkyl, perfluoro Cl-C6 alkyl, perfluoroC,-C6 alkoxy, Cl-C6 alkylamino, di- C1-C6 alkylamino, aminoC1-C6 alkyl, Cl-C6 alkylaminoC,-C6 alkyl, di-Cl-C6 alkylaminoC,-C6 alkyl, CI-C6acyl, C1-C6acyloxy, Cl-C6acyloxyC,-C6 alkyl, Cl-C6 acylamino, Cl-C6 alkylthio, C1-C6 alkylthiocarbonyl, C1-C6 alkylthioxo, C1-C6 alkoxycarbonyl, Cl-C6 alkylsulfonyl, C1-C6 alkylsulfonylamino, aminosulfonyl, Cl-C6 alkylaminosulfonyl, di-Cl-C6 alkylaminosulfonyl, 3-8 membered cycloalkyl, 4-8 membered heterocycloalkyl, phenyl and monocyclic heteroaryl; or a pharmaceutically acceptable salt, solvate or pro-drug thereof.