866489-00-1

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 102195-80-2 (S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 686766-59-6 4-(3-fluoro-benzylidene)-pyrrolidine-1,2-dicarboxylic acid-1-tert butyl ester 2-methyl ester 

Downstream Products

• 1217779-98-0 (2S,4S)-4-(3-fluoro-benzyl)-pyrrolidine-2-carboxylic acid mono hydrochloride salt 
• 1217779-98-0 (R)-γ-(3-fluorobenzyl)-L-proline hydrochloride 

Relevant academic research and scientific papers

Part 3: Design and synthesis of proline-derived α2δ ligands

A potent series of substituted (2S,4S)-benzylproline α 2δ ligands have been designed from the readily available starting material (2S,4R)-hydroxy-l-proline. The ligands have improved pharmacokinetic profile over the (4S)-phenoxyproline derivati

PROCESS FOR THE RECRYSTALLISATION OF PROLINE DERIVATES

A procees for the preparation of benzyl-pyrrolidine-2-carboxylic acid derivatives in essentially diastereomerically pure form using recrystallisation is provided.