1217854-15-3

Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one is used as a potential pharmaceutical compound for its unique structure and functional groups, which may offer novel therapeutic applications after further research and analysis.
Used in Organic Synthesis:
In the field of organic chemistry, (R)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one serves as a reagent that could be utilized in the synthesis of other complex organic molecules, taking advantage of its specific stereochemistry and functional groups.

Upstream product

• 21667-60-7 3-methoxybenzoylacetonitrile 
• 197145-37-2 3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one 
• 2743-38-6 O,O'-dibenzoyl-L-tartaric acid 

Relevant academic research and scientific papers

Asymmetric Transfer Hydrogenation of α-Substituted-β-Keto Carbonitriles via Dynamic Kinetic Resolution

A catalytic protocol for the enantio- and diastereoselective reduction of α-substituted-β-keto carbonitriles is described. The reaction involves a DKR-ATH process with the simultaneous construction of β-hydroxy carbonitrile scaffolds with two contiguous stereogenic centers. A wide range of α-substituted-β-keto carbonitriles were obtained in high yields (94%-98%) and excellent enantio- and diastereoselectivities (up to >99% ee, up to >99:1 dr). The origin of the diastereoselectivity was also rationalized by DFT calculations. Furthermore, this methodology offers rapid access to the pharmaceutical intermediates of Ipenoxazone and Tapentadol.

PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL

The present invention relates to a process for the preparation of (1 R,2R)-3- dimethylamino-1-ethyl-2-methyl-propyl)-phenol.

PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE

The present invention relates to an improved process for the preparation of (2R,3R)-3- (3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol.