121872-95-5

Usage

Uses

Used in Biochemistry:
2-Chloro-4,5-Difluorobenzoyl Chloride is used as a reactant in various synthesis processes for the development of new biochemical compounds. Its unique combination of chlorine and fluorine elements contributes to its reactivity, which is essential for creating novel molecules with potential applications in research and medicine.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Chloro-4,5-Difluorobenzoyl Chloride is employed as a key reactant for the creation of new organic compounds. Its reactivity allows for the formation of complex molecules that can be used in pharmaceuticals, agrochemicals, or other industrial applications.
Used in Pharmaceutical Industry:
2-Chloro-4,5-Difluorobenzoyl Chloride is used as an intermediate in the synthesis of pharmaceutical compounds. Its role in creating new drug molecules is crucial, as it can contribute to the development of novel treatments for various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4,5-Difluorobenzoyl Chloride is utilized as a building block for the synthesis of new agrochemical products. Its reactivity enables the creation of innovative compounds that can be used in crop protection and other agricultural applications.
Used in Industrial Applications:
2-Chloro-4,5-Difluorobenzoyl Chloride is employed as a reactant in the synthesis of various industrial chemicals. Its versatility in forming new compounds makes it a valuable component in the development of materials for a wide range of uses, from plastics to coatings.

InChI:InChI=1/C7H2Cl2F2O/c8-4-2-6(11)5(10)1-3(4)7(9)12/h1-2H

Upstream product

• 136364-59-5 2-chloro-4,5-difluorobenzotrichloride 
• 110877-64-0 2-chloro-4,5-difluorobenzoic acid 

Downstream Products

• 675574-55-7 2-chloro-4,5-difluoro-benzoic acid N'-(2,4-dichloro-5-fluoro-benzoyl)-hydrazide 
• 121872-97-7 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester 
• 916032-76-3 2-chloro-4,5-difluoro-N-(1-phenylethyl)benzamide 
• 1383572-74-4 N-benzyl-4,5-difluoro-2-hydroxybenzamide 
• 710981-36-5 N-benzyl-4,5-difluoro-2-chlorobenzamide 
• 915787-94-9 5-(2-chloro-4,5-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 121872-99-9 (2-chloro-4,5-difluorobenzoyl)propanedioic acid diethyl ester 
• 85721-33-1 ciprofloxacin 
• 128800-36-2 2-Chloro-4,5-difluorobenzoic acid methyl ester 
• 132630-82-1 2-(6-chloro-3,4-difluoro-2-methylphenyl)-4,4-dimethyl-2-oxazoline 

Relevant academic research and scientific papers

A highly efficient copper-catalyzed method for the synthesis of 2-hydroxybenzamides in water

An efficient copper-catalyzed synthetic method for the preparation of 2-hydroxybenzamides is described for the first time from 2-chlorobenzamide substrates using copper iodide/1,10-phenanthroline and a base, potassium hydroxide, in neat water. By using this reaction, a series of 2-hydroxybenzamides with functional groups such as fluoro, chloro, iodo, methoxy, amide, and alcohol have been obtained in 33-96% yield. Other aromatic 2-chloroarylamides such as naphthalene, pyridine, and thiophene are found to be equally compatible to the reaction. It is proposed that the reaction proceed via formation of copper-amide complex, which may facilitate the hydroxylation in water. Overall, the first report on copper-catalyzed hydroxylation reaction in water and first catalytic route for the synthesis of 2-hydroxybenzamides is presented. Simple purification procedure and convenience of employing low-cost reagents in neat water make this method practical and economical for the synthesis of 2-hydroxybenzamides. Georg Thieme Verlag Stuttgart · New York.

Cu-catalyzed efficient synthetic methodology for ebselen and related se-N heterocycles

An efficient copper-catalyzed method for the synthesis of biologically important ebselen and related analogues containing a Se-N bond has been developed. This is the first report of a catalytic process of selenation and Se-N bond formation reaction. Copper-catalyzed reaction tolerates functional groups such as amides, hydroxyls, ethers, nitro, fluorides, and chlorides. The best results are obtained by using a combination of potassium carbonate as a base, iodo- or bromo-arylamide substrates, selenium powder, and copper iodide catalyst.

PYRAZOLE COMPOUNDS AND USE THEREOF

The pyrazole compound of the present invention is represented by the following general formula (I). The pyrazole compound of the present invention or a salt thereof or a solvate thereof potently inhibits liver glycogen phosphorylase, and, therefore, is useful as a therapeutic or prophylactic agent for diabetes. wherein each symbol denotes as described in the specifications.

NOVEL COMPOUNDS

The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME

A pyrazole compound represented by the general formula (I) or a salt thereof which has a hepatic glycogen phosphorylase inhibitory activity and therefore is useful as a therapeutic or prophylactic agent for diabetes or a pharmacologically salt thereof : wherein the ring Q represents an aryl group or an aromatic heterocyclic group; R1 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group; R2 represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or an azide group; R3 represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a halo-C1-6 alkyl group, a C1-6 alkoxy group, an azide group, an amino group, an acylamino group or a C1-6 alkylsulfonylamino group; R4 and R5 independently represent a hydrogen atom, a C1-6 alkyl group which may be substituted, a a C3-8 cycloalkyl group, a saturated heterocyclic group which may be substituted, an aryl group which may be substituted, a C7-14 aralkyl group, an aromatic heterocyclic group or the like.

PROCESSES FOR THE PREPARATION OF PYRAZOLO[1,5-a]-1,3,5-TRIAZINES AND INTERMEDIATES THEREOF

The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression.

Method of preparing fluoroaromatic compounds

The present invention provides a method of preparing ortho-difluorobenzene derivatives, which comprises (a) providing a mixture of cyclohexenes by reacting chlorotrifluoroethylene (CTFE) and 1,3-diene in a flow reactor and distilling the resultant, and (b) dehydrohalogenating the mixture of cyclohexenes with a phase transition catalyst in the presence of alkali metal hydroxide at temperature range of 40 to 150 °C without using any organic solvent. The distillate having low boiling point, which is obtained during distillation of the resultant, is recycled into the flow reactor. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoic acid, which comprises (a) providing a mixture of 4-chloro-1-methyl-4,5,5-trifluorocyclohexene and 5-chloro-1-methyl-4,4,5-trifluorocyclohexene by reacting chlorotrifluoroethylene (CTFE) and isoprene and distilling the resultant, (b) dehydrohalogenating said mixture in the presence of alkali metal hydroxide and a phase transition catalyst to form 3,4-difluorotoluene, (c) reacting said 3,4-difluorotoluene with chlorine gas without using any organic solvent to form 2-chloro-4,5-difluorotoluene, (d) photo-reacting said 2-chloro-4,5-difluorotoluene with chlorine gas under a lighting mercury lamp without using any organic solvent to form 2-chloro-4,5-difluorobenzotrichloride, and (e) reacting said 2-chloro-4,5-difluorobenzotrichloride with aqueous acid solution without using any organic solvent. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoyl chloride by reacting the 2-chloro-4,5-difluorobenzotrichloride of step (e) above with zinc oxide.

Method of preparing fluoroaromatic compounds

The present invention provides a method of preparing ortho-difluorobenzene derivatives, which comprises (a) providing a mixture of cyclohexenes by reacting chlorotrifluoroethylene (CTFE) and 1.3-diene in a flow reactor and distilling the resultant, and (b) dehydrohalogenating the mixture of cyclohexenes with a phase transition catalyst in :he presence of alkali metal hydroxide at temperature range of 40 to 150° C. without using any organic solvent. The distillate having low boiling point, which is obtained during distillation of the resultant, is recycled into the flow reactor. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoic acid, which comprises (a) providing a mixture of 4-chloro-1-methyl-4,5,5-trifluorocyclohexene and 5-chloro-1-methyl-4,4,5-trifluorocyclohexene by reacting chlorotrifluoroethylene (CTFE) and isoprene and distilling the resultant. (b) dehydrohalogenating said mixture in the presence of alkali metal hydroxide and a phase transition catalyst to form 3,4-difluorotoluene, to reacting said 3,4-difluorotoluene with chlorine gas without using any organic solvent to form 2-chloro-4,5-difluorotoluene, (d) photo-reacting said 2-chloro-4,5-difluorotoluene with chlorine gas under a lighting mercury lamp without using any organic solvent to form 2-chloro-4,5-difluorobenzotrichloride, and (e) reacting said 2-chloro-4,5-difluorobenzotrichloride with aqueous acid solution without using any organic solvent. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoyl chloride by reacting the 2-chloro-4,5-difluorobenzotrichloride of step (e) above with zinc oxide.

PREPARATION OF 1-HYDROXYXANTHEN-9(9H)-ONES AND 1-HYDROXYACRIDIN-9(10H)-ONES VIA CORRESPONDING 3,4-DIHYDRO-1,9(2H)-DIONES

Target 10-cyclopropyl-7-fluoro-6-(4-methyl-1-piperazinyl)acridin-9(10H)-one (IVc) and 7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)-9H-xanthen-9-one (IVd) were obtained from corresponding difluoro derivatives IVa and IVb, respectively.These intermediates were synthesized via respective 3,4-dihydro-1,9(2H)-diones Va and Vb.Acridine derivative (10-cyclopropyl-6,7-difluoro-3,4-dihydro-1H-acridine-1,9(2H,10H)-dione, Va) was synthesized from 1-cyclopropyl-6,7-difluoroisatoic anhydride (XI) and xanthene derivative (6,7-difluoro-3,4-dihydro-1H-xanthen-1,9(2H)-dione, Vb) from cyclohexenone derivative VIb.Several unsuccessful attempts to prepare hydroxyacridone IVc and/or some useful intermediates of its synthesis are also described.

Fluorinated benzoyl compounds

A 2-chloro-4,5-difluorobenzoyl compound of the formula: STR1 wherein R2 is a lower alkyl group, and R7 is a 2,4-difluorophenyl group or a 4-fluorophenyl group.