121872-95-5

Basic information

• Product Name: 2-CHLORO-4,5-DIFLUOROBENZOYL CHLORIDE
• Synonyms: 2-CHLORO-4,5-DIFLUOROBENZOYL CHLORIDE;Benzoyl chloride, 2-chloro-4,5-difluoro- (9CI);2-Chloro-4,5-difluorobenzoyl chloride 98%;2-Chloro-4,5-difluorobenzoylchloride98%
• CAS NO: 121872-95-5
• Molecular Formula: C₇H₂Cl₂F₂O
• Molecular Weight: 210.99
• Product Categories: ACIDHALIDE
• Mol File: 121872-95-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 217.8 °C at 760 mmHg
• Flash Point: 85.5 °C
• Appearance: /
• Density: 1.548 g/cm³
• Vapor Pressure: 0.13mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 2-CHLORO-4,5-DIFLUOROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4,5-DIFLUOROBENZOYL CHLORIDE(121872-95-5)
• EPA Substance Registry System: 2-CHLORO-4,5-DIFLUOROBENZOYL CHLORIDE(121872-95-5)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• Hazardous Substances Data: 121872-95-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-4,5-Difluorobenzoyl Chloride is a chemical compound noted for its unique combination of chlorine and fluorine elements. It is a chlorinated and fluorinated derivative of benzoyl chloride, characterized under the family of organofluorines and benzenoids. Often used in the field of biochemistry and organic synthesis, this chemical is a useful reactant in various synthesis processes due to its reactivity. Care and caution are needed when handling this chemical due to its potential hazard, as it is corrosive to metals and skin, and fatal if inhaled.

InChI:InChI=1/C7H2Cl2F2O/c8-4-2-6(11)5(10)1-3(4)7(9)12/h1-2H

Upstream product

• 136364-59-5 2-chloro-4,5-difluorobenzotrichloride 
• 110877-64-0 2-chloro-4,5-difluorobenzoic acid 

Downstream Products

• 121872-97-7 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester 
• 916032-76-3 2-chloro-4,5-difluoro-N-(1-phenylethyl)benzamide 
• 1383572-74-4 N-benzyl-4,5-difluoro-2-hydroxybenzamide 
• 710981-36-5 N-benzyl-4,5-difluoro-2-chlorobenzamide 
• 915787-94-9 5-(2-chloro-4,5-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 121872-99-9 (2-chloro-4,5-difluorobenzoyl)propanedioic acid diethyl ester 
• 85721-33-1 ciprofloxacin 
• 128800-36-2 2-Chloro-4,5-difluorobenzoic acid methyl ester 
• 132630-82-1 2-(6-chloro-3,4-difluoro-2-methylphenyl)-4,4-dimethyl-2-oxazoline 
• 132630-81-0 2-(2-chloro-4,5-difluorophenyl)-4,4-dimethyl-2-oxazoline 
• 175476-13-8 2-(2-chloro-4,5-difluorobenzoyl)-1,3-cyclohexandione 
• 175476-19-4 2-(2-chloro-4,5-difluorobenzoyl)-1,3-dihydroxybenzene 

Relevant articles and documents

A highly efficient copper-catalyzed method for the synthesis of 2-hydroxybenzamides in water

An efficient copper-catalyzed synthetic method for the preparation of 2-hydroxybenzamides is described for the first time from 2-chlorobenzamide substrates using copper iodide/1,10-phenanthroline and a base, potassium hydroxide, in neat water. By using this reaction, a series of 2-hydroxybenzamides with functional groups such as fluoro, chloro, iodo, methoxy, amide, and alcohol have been obtained in 33-96% yield. Other aromatic 2-chloroarylamides such as naphthalene, pyridine, and thiophene are found to be equally compatible to the reaction. It is proposed that the reaction proceed via formation of copper-amide complex, which may facilitate the hydroxylation in water. Overall, the first report on copper-catalyzed hydroxylation reaction in water and first catalytic route for the synthesis of 2-hydroxybenzamides is presented. Simple purification procedure and convenience of employing low-cost reagents in neat water make this method practical and economical for the synthesis of 2-hydroxybenzamides. Georg Thieme Verlag Stuttgart · New York.

PYRAZOLE COMPOUNDS AND USE THEREOF

The pyrazole compound of the present invention is represented by the following general formula (I). The pyrazole compound of the present invention or a salt thereof or a solvate thereof potently inhibits liver glycogen phosphorylase, and, therefore, is useful as a therapeutic or prophylactic agent for diabetes. wherein each symbol denotes as described in the specifications.

PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME

A pyrazole compound represented by the general formula (I) or a salt thereof which has a hepatic glycogen phosphorylase inhibitory activity and therefore is useful as a therapeutic or prophylactic agent for diabetes or a pharmacologically salt thereof : wherein the ring Q represents an aryl group or an aromatic heterocyclic group; R1 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group; R2 represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or an azide group; R3 represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a halo-C1-6 alkyl group, a C1-6 alkoxy group, an azide group, an amino group, an acylamino group or a C1-6 alkylsulfonylamino group; R4 and R5 independently represent a hydrogen atom, a C1-6 alkyl group which may be substituted, a a C3-8 cycloalkyl group, a saturated heterocyclic group which may be substituted, an aryl group which may be substituted, a C7-14 aralkyl group, an aromatic heterocyclic group or the like.