121872-97-7

Upstream product

• 121872-99-9 (2-chloro-4,5-difluorobenzoyl)propanedioic acid diethyl ester 
• 676-58-4 methylmagnesium chloride 
• 6148-64-7 ethyl potassium malonate 
• 121872-95-5 2-chloro-4,5-difluorobenzoyl chloride 
• 623-49-4 ethyl cyanoformate 
• 121872-94-4 2'-chloro-4',5'-difluoroacetophenone 

Downstream Products

• 121873-02-7 2-chloro-α-(ethoxymethylene)-4,5-difluoro-β-oxobenzenepropanoic acid,ethyl ester 
• 535170-24-2 ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 179739-43-6 1-(5-amino-2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 121872-98-8 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester 

Relevant academic research and scientific papers

Preparation of beta-ketoesters useful in preparing quinolone antibiotics

A method for preparing a compound of the formula STR1 wherein Q is C--H or N; R1 is C1-C4 alkyl, benzyl or p-nitrobenzyl and X and Y are independently selected from fluoro and chloro comprising reacting a compound of the f

Fluorinated benzoyl compounds

A 2-chloro-4,5-difluorobenzoyl compound of the formula: STR1 wherein R2 is a lower alkyl group, and R7 is a 2,4-difluorophenyl group or a 4-fluorophenyl group.

Process for preparing fluorinated benzoyl compounds

Fluorinated benzoyl compounds of the formula: STR1 wherein Q is a lower alkyl group, a halogen atom, --CH2 CO2 R1 wherein R1 is a lower alkyl group, or STR2 wherein each of R2 and R3 is a lower alkyl group, are disclosed.

Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters

Compounds of the formula: wherein Y is OR1, fluoro, chloro, methyl, R1, and R3 are independently selected from hydrogen and C1-C4 alkyl, R2 is C1-C4 alkyl and X is fluoro, chloro or bromo, with the proviso that when Y is OH, X cannot be bromo and with the proviso that X can be fluoro only if R2 is methyl.

Process for preparing 2-chloro-4,5-difluorobenzoic acid

This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quinoli necarboxylic acid antibacterial agents.