1219-02-9

Basic information

• Product Name: 1-(2-methoxyphenyl)-3-phenylthiourea
• CAS NO: 1219-02-9
• Molecular Formula: C₁₄H₁₄N₂OS
• Molecular Weight: 258.3388
• Mol File: 1219-02-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 383.9°C at 760 mmHg
• Flash Point: 185.9°C
• Density: 1.28g/cm³
• Vapor Pressure: 4.27E-06mmHg at 25°C
• Refractive Index: 1.712
• CAS DataBase Reference: 1-(2-methoxyphenyl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxyphenyl)-3-phenylthiourea(1219-02-9)
• EPA Substance Registry System: 1-(2-methoxyphenyl)-3-phenylthiourea(1219-02-9)

Safety Data

• Hazardous Substances Data: 1219-02-9(Hazardous Substances Data)

Usage

General Description

1-(2-methoxyphenyl)-3-phenylthiourea is a chemical compound with the molecular formula C14H14N2OS. It is a thiourea derivative with a substituted phenyl group and a methoxy group. Thioureas are known for their diverse biological activities and have been studied for their potential medicinal and agricultural uses. This particular compound may have applications in drug development due to its unique structure and potential pharmacological properties. Further research is needed to fully understand the potential uses and effects of 1-(2-methoxyphenyl)-3-phenylthiourea.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 248279-10-9 N,N'-bis-(2-methoxy-phenyl)-S-methyl-isothiourea 
• 1226-64-8 1,3-bis-(2-methoxy-phenyl)-thiourea 
• 62-53-3 aniline 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 1308272-88-9 (2-methoxyphenyl)-(1-phenyl-1H-tetrazol-5-yl)-amine 
• 1308272-98-1 [1-(2-methoxyphenyl)-1H-tetrazol-5-yl]phenylamine 
• 1262995-48-1 C₁₆H₁₆N₂O₃ 
• 1262995-43-6 C₁₆H₁₆N₂O₃ 
• 86128-87-2 N-(2-Methoxy-phenyl)-N'.N'-diphenyl-guanidin 
• 111022-17-4 1-(2-Methoxy-phenyl)-3-phenyl-thiourea; compound with 2,3-dicyano-but-2-enedinitrile 
• 32826-78-1 3-(2-methoxy-phenyl)-2-phenylimino-thiazolidin-4-one 
• 7669-23-0 [3-(2-methoxy-phenyl)-4-oxo-2-phenylimino-thiazolidin-5-yl]-acetic acid 

Relevant articles and documents

Hydroamination of isocyanates and isothiocyanates by alkaline earth metal initiators supported by a bulky iminopyrrolyl ligand

A series of new heteroleptic alkaline earth (Ae) metal complexes of general formula [{(Ph2CHN-CH)2C4H2N}AeI(THF)3] {Ae = Ca (2), Sr (3), and Ba (4)} were synthesizedviasalt metathesis by reacting potassium salt of ligand1-K[{(Ph2CHN-CH)2C4H2N}K(THF)2] with anhydrous alkaline earth metal diiodides (AeI2). The homoleptic calcium and barium complexes [{(Ph2CHN-CH)2C4H2N}2Ae] [Ae = Ca (5), Ba (6)] were prepared by treating metal bis-hexamethyldisilazide [Ae{N(SiMe3)2}2(THF)2] with the protic ligand1-H[(Ph2CH-N-CH)2C4H2NH] in a 1:2 molar ratio. Calcium complex5was used as an active pre-catalyst for the addition of N-H bond of arylamines across the heterocumulenes such as phenylisocyanate (PhNCO) and phenylisothiocyanate (PhNCS) under neat conditions, and up to 99% yields of the corresponding urea and thiourea derivatives were obtained.

Tandem regioselective synthesis of tetrazoles and related heterocycles using iodine

A one-pot, tandem process has been developed for the synthesis of a library of tetrazoles from aryl isothiocyanates. Condensation of aryl isothiocyanates with ammonia, and aryl amines (R-NH2) provided mono, 1,3-disubstituted symmetrical and unsymmetrical thioureas, which on desulfurization with molecular iodine (I2) led to formation of the corresponding heterocumulene (cyanamides or carbodiimides). The in situ generated heterocumulene on subsequent treatment with sodium azide at room temperature gave corresponding tetrazoles. The product regioselectivity for unsymmetrical 1,3-disubstituted thioureas was found to be correlated with the basicities (pKa's) of the parent amines attached to the thiourea. Aryl-sec-alkyl unsymmetrical thioureas gave thioamido guanidino products rather than the 5-aminotetrazoles produced by HgCl2 mediation of the reaction. Bis-thioureas derived from aryl isothiocyanates and hydrazine gave thiadiazoles exclusively.