1219-02-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-methoxyphenyl)-3-phenylthiourea is used as a potential drug candidate for its diverse biological activities. Its unique structure and potential pharmacological properties make it a valuable compound for drug development, particularly in the search for new therapeutic agents.
Used in Agricultural Industry:
1-(2-methoxyphenyl)-3-phenylthiourea may also have applications in the agricultural sector, possibly as a component in the development of new pesticides or other agrochemicals. Its potential biological activities could be harnessed to create more effective and targeted products for crop protection and management.
Note: The specific applications in the pharmaceutical and agricultural industries are not explicitly mentioned in the provided materials. The uses listed above are inferred based on the general knowledge of thiourea derivatives and their potential applications in these fields. Further research and development would be required to confirm and expand upon these potential uses.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 103-72-0 phenyl isothiocyanate 
• 62-53-3 aniline 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 
• 248279-10-9 N,N'-bis-(2-methoxy-phenyl)-S-methyl-isothiourea 
• 1226-64-8 1,3-bis-(2-methoxy-phenyl)-thiourea 

Downstream Products

• 111022-17-4 1-(2-Methoxy-phenyl)-3-phenyl-thiourea; compound with 2,3-dicyano-but-2-enedinitrile 
• 86128-87-2 N-(2-Methoxy-phenyl)-N'.N'-diphenyl-guanidin 
• 1262995-48-1 C₁₆H₁₆N₂O₃ 
• 1262995-43-6 C₁₆H₁₆N₂O₃ 
• 1308272-88-9 (2-methoxyphenyl)-(1-phenyl-1H-tetrazol-5-yl)-amine 
• 1308272-98-1 [1-(2-methoxyphenyl)-1H-tetrazol-5-yl]phenylamine 
• 7669-23-0 [3-(2-methoxy-phenyl)-4-oxo-2-phenylimino-thiazolidin-5-yl]-acetic acid 
• 32826-78-1 3-(2-methoxy-phenyl)-2-phenylimino-thiazolidin-4-one 

Relevant academic research and scientific papers

Hydroamination of isocyanates and isothiocyanates by alkaline earth metal initiators supported by a bulky iminopyrrolyl ligand

A series of new heteroleptic alkaline earth (Ae) metal complexes of general formula [{(Ph2CHN-CH)2C4H2N}AeI(THF)3] {Ae = Ca (2), Sr (3), and Ba (4)} were synthesizedviasalt metathesis by reacting potassium salt of ligand1-K[{(Ph2CHN-CH)2C4H2N}K(THF)2] with anhydrous alkaline earth metal diiodides (AeI2). The homoleptic calcium and barium complexes [{(Ph2CHN-CH)2C4H2N}2Ae] [Ae = Ca (5), Ba (6)] were prepared by treating metal bis-hexamethyldisilazide [Ae{N(SiMe3)2}2(THF)2] with the protic ligand1-H[(Ph2CH-N-CH)2C4H2NH] in a 1:2 molar ratio. Calcium complex5was used as an active pre-catalyst for the addition of N-H bond of arylamines across the heterocumulenes such as phenylisocyanate (PhNCO) and phenylisothiocyanate (PhNCS) under neat conditions, and up to 99% yields of the corresponding urea and thiourea derivatives were obtained.

Synthesis of some 3,5-disubstituted phenyl-5,6-dihydrofuro[2,3-d]thiazol-2(3H)-ylidene) imines as potential pesticides

A new series of novel 3,5-disubstituted phenyl-5,6-dihydrofuro[2,3-d]thiazol-2(3H)-ylidene) imines have been synthesized from a common intermediate, in good yield. These compounds have been screened for their herbicidal activities against èchinochloa oryzicola, Echinochloa crus-galli, Oryza sativa, Glycine max and antifungal activities against Aspergillus Niger and Pyricularia oryzae whereas for antimicrobial activities, they have been screened against Salmonella typhi, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Bacillus pumilus.

Tandem regioselective synthesis of tetrazoles and related heterocycles using iodine

A one-pot, tandem process has been developed for the synthesis of a library of tetrazoles from aryl isothiocyanates. Condensation of aryl isothiocyanates with ammonia, and aryl amines (R-NH2) provided mono, 1,3-disubstituted symmetrical and unsymmetrical thioureas, which on desulfurization with molecular iodine (I2) led to formation of the corresponding heterocumulene (cyanamides or carbodiimides). The in situ generated heterocumulene on subsequent treatment with sodium azide at room temperature gave corresponding tetrazoles. The product regioselectivity for unsymmetrical 1,3-disubstituted thioureas was found to be correlated with the basicities (pKa's) of the parent amines attached to the thiourea. Aryl-sec-alkyl unsymmetrical thioureas gave thioamido guanidino products rather than the 5-aminotetrazoles produced by HgCl2 mediation of the reaction. Bis-thioureas derived from aryl isothiocyanates and hydrazine gave thiadiazoles exclusively.

Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N-diaryl unsymmetrically substituted thioureas

Fourteen N,N-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic (in vitro), phytotoxic (in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.