1219013-92-9

Upstream product

• 153775-33-8 2,4-difluoro-5-nitro-benzoic acid 
• 1583-58-0 2,4-difluoro-benzoic acid 

Downstream Products

• 1374298-79-9 7-[(2,6-dichlorophenyl)amino]-2-methyl-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylic acid 
• 1374298-83-5 methyl 7-[(2,6-dichlorophenyl)amino]-2-methyl-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate 
• 1374298-89-1 methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate 
• 1374295-92-7 N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide 
• 1374297-72-9 7-[(2,6-Dichlorophenyl)amino]-N-(4-fluorophenyl)-2-methyl-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxamide 
• 1374297-76-3 7-[(2,6-Dichlorophenyl)amino]-N-hexyl-2-methyl-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxamide 
• 1374298-88-0 methyl 7-amino-2-[(2,6-dichlorophenyl)amino]-6-hydroxy-1H-benzimidazole-5-carboxylate 
• 1374298-82-4 methyl 2-[(2,6-dichlorophenyl)amino]-6-hydroxy-7-nitro-1H-benzimidazole-5-carboxylate 
• 1374298-81-3 methyl 2-[(2,6-dichlorophenyl)amino]-6-hydroxy-1H-benzimidazole-5-carboxylate 
• 1374298-80-2 methyl 4,5-diamino-2-hydroxybenzoate 
• 1374298-76-6 methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate 
• 1374298-17-5 methyl 4-amino-2-hydroxy-3-(2-methylprop-2-en-1-yl)-5-nitrobenzoate 
• 1374298-16-4 methyl 4-amino-2-((2-methylallyl)oxy)-5-nitrobenzoate 
• 1374298-19-7 methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate 

Relevant academic research and scientific papers

Tricyclic Compounds As mPGES-1 Inhibitors

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.