121944-93-2

Upstream product

• 116428-35-4 (6R)-trans-4-p-tolyl-6-trimethylsilyl-2-oxepanone 
• 116428-36-5 methyl (3S,5R)-6-hydroxy-3-p-tolyl-5-(trimethylsilyl)hexenoate 
• 121944-92-1 methyl (R)-(-)-3-p-tolyl-5-hexanoate 

Downstream Products

• 69657-27-8 (S)-4-(4-methylphenyl)pentan-2-one 
• 121946-72-3 2-Methyl-2-((S)-2-p-tolyl-propyl)-[1,3]dioxolane 
• 121944-95-4 (S)-4-(2-Methyl-[1,3]dioxolan-2-yl)-3-p-tolyl-butyraldehyde 
• 121944-94-3 (-)-methyl 5-oxo-3-(p-tolyl)hexenoate 

Relevant academic research and scientific papers

SYNTHESIS OF (+)-α-CURCUMENE, (+)-CURCUMONE AND (-)-METHYL CITRONELLATE STARTING FROM OPTICALLY PURE 5-TRIMETHYLSILYL-2-CYCLOHEXENONE

1,4-addition of Grignard reagents in the presence of chlorotrimethylsilane to 5-trimethylsilyl-2-cyclohexanone (1) proceeded in a highly diastereoselective manner to give trans adducts in high yields. (+)-α-Curcumene, (+)-curcumone and (-)-methyl citronellate were synthesized starting from optically pure 1.