121946-72-3

Upstream product

• 116428-41-2 1-Methyl-4-((1S,5S)-5-trimethylsilanyl-3-trimethylsilanyloxy-cyclohex-2-enyl)-benzene 
• 121944-94-3 (-)-methyl 5-oxo-3-(p-tolyl)hexenoate 
• 121944-93-2 methyl (R)-5-oxo-3-(p-tolyl)hexanoate 
• 121944-92-1 methyl (R)-(-)-3-p-tolyl-5-hexanoate 
• 116428-36-5 methyl (3S,5R)-6-hydroxy-3-p-tolyl-5-(trimethylsilyl)hexenoate 
• 116428-35-4 (6R)-trans-4-p-tolyl-6-trimethylsilyl-2-oxepanone 
• 121944-95-4 (S)-4-(2-Methyl-[1,3]dioxolan-2-yl)-3-p-tolyl-butyraldehyde 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 116428-36-5 methyl (3SR,5RS)-6-hydroxy-3-p-tolyl-5-(trimethylsilyl)hexenoate 
• 121944-94-3 methyl 5-oxo-3-(p-tolyl)hexenoate 
• 116428-35-4 (+/-)-trans-4-p-tolyl-6-trimethylsilyl-2-oxepanone 
• 118527-94-9 methyl 5-oxo-3-(p-tolyl)hexanoate 
• 118527-87-0 methyl 3-p-tolyl-5-hexanoate 
• 121944-95-4 4-(2-Methyl-[1,3]dioxolan-2-yl)-3-p-tolyl-butyraldehyde 

Downstream Products

• 451-25-2 4-(4-methylphenyl)pentan-2-one 
• 69657-27-8 (S)-4-(4-methylphenyl)pentan-2-one 

Relevant academic research and scientific papers

SYNTHESIS OF (+)-α-CURCUMENE, (+)-CURCUMONE AND (-)-METHYL CITRONELLATE STARTING FROM OPTICALLY PURE 5-TRIMETHYLSILYL-2-CYCLOHEXENONE

1,4-addition of Grignard reagents in the presence of chlorotrimethylsilane to 5-trimethylsilyl-2-cyclohexanone (1) proceeded in a highly diastereoselective manner to give trans adducts in high yields. (+)-α-Curcumene, (+)-curcumone and (-)-methyl citronellate were synthesized starting from optically pure 1.