1219624-75-5

Basic information

• Product Name: 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one
• Synonyms: 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one
• CAS NO: 1219624-75-5
• Molecular Weight: 535.609
• Mol File: 1219624-75-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one(1219624-75-5)
• EPA Substance Registry System: 1-(2-oxo-2-{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one(1219624-75-5)

Safety Data

• Hazardous Substances Data: 1219624-75-5(Hazardous Substances Data)

Upstream product

• 24056-59-5 3,3-Diphenylpiperidin-2-one 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 1219624-63-1 ethyl 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetate 
• 60011-04-3 (2-oxo-3,3-diphenyl-piperidin-1-yl)-acetic acid 
• 107890-32-4 1-(4-trifluoromethylbenzyl)piperazine 

Relevant articles and documents

Discovery of diphenyl lactam derivatives as N-type calcium channel blockers

A novel series of diphenyl lactam containing calcium channel blockers is described. Extensive SAR studies resulted in compounds with low molar activity and good plasma exposure after oral dosing. Compounds 2, 6 and 7 demonstrated significant efficacy in the capsaicin model of secondary hyperalgesia following oral administration.