121963-39-1Relevant academic research and scientific papers
A convenient synthesis of 2-nitroindoles
Roy, Sujata,Gribble, Gordon W.
, p. 1325 - 1328 (2005)
The reaction of 2-iodo- and 2-bromoindoles with silver nitrite in aqueous acetone affords the corresponding 2-nitroindoles in modest to good yields.
A novel bis-indole destabilizes Microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer
Ahn, Sunjoo,Hwang, Dong Jin,Barrett, Christina M.,Yang, Jun,Duke III, Charles B.,Miller, Duane D.,Dalton, James T.
scheme or table, p. 293 - 304 (2011/11/06)
Purpose: Microtubules are one of the most useful subcellular targets in chemotherapy. We identified a novel indole, (3-(1H-indol-2-yl)phenyl)(1H-indol- 2-yl)methanone (15), that inhibits tubulin action and exhibits potent antitumor activity in various pre
Indoles, Derivatives, and Analogs Thereof and Uses Therefor
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Page/Page column title page; 8; sheet 1; sheet 10, (2009/06/27)
Indole derivatives and analog compounds and pharmaceutical compositions comprising the same are provided. Also provided are methods of using these compounds to inhibit tubulin polymerization in a cell associated with a proliferative disease or to treat a
Synthesis of Alkyl-Substituted N-Protected Indoles via Acylation and Reductive Deoxygenation
Ketcha, Daniel M.,Lieurance, Brett A.,Homan, Dominic F. J.,Gribble, Gordin W.
, p. 4350 - 4356 (2007/10/02)
The synthesis of 2-, 3-, and 5-alkyl-1-(phenylsulfonyl)indoles involving Friedel-Crafts acylation followed by reductive deoxygenation is described.The application of this acylation-deoxygenation sequence to 3-acyl-1-(phenylsulfonyl)indoles bearing potenti
