1345675-25-3 Usage
Uses
Used in Pharmaceutical Industry:
E6446 (dihydrochloride) is used as an immunomodulatory agent for its ability to specifically inhibit the activation of human and mouse TLR9 at low doses. This property makes it a valuable compound in the development of treatments for conditions involving the overactivation of TLR9, such as autoimmune diseases and inflammatory disorders.
Used in Infectious Disease Treatment:
In the context of acute Plasmodium infection, E6446 (dihydrochloride) is used as an anti-inflammatory agent to diminish the activation of TLR9 and prevent the exacerbated cytokine response. This helps in reducing the severity of the disease and its associated complications.
Used in ECM (Encephalomyelitis) Treatment:
E6446 (dihydrochloride) is used as a therapeutic agent for the prevention and treatment of severe signs of ECM, such as limb paralysis, brain vascular leak, and death. Oral treatment with E6446 has been shown to be effective in preventing these severe manifestations of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 1345675-25-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,5,6,7 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1345675-25:
(9*1)+(8*3)+(7*4)+(6*5)+(5*6)+(4*7)+(3*5)+(2*2)+(1*5)=173
173 % 10 = 3
So 1345675-25-3 is a valid CAS Registry Number.
1345675-25-3Relevant academic research and scientific papers
BENZOXAZOLE COMPOUNDS AND METHODS OF USE
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Page/Page column 28, (2010/04/27)
The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides methods of use as described herein.
USE OF BENZOXAZOLE COMPOUNDS IN THE TREATMENT OF MALARIA
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, (2010/04/27)
The present invention provides methods of preventing or treating malaria using benzoxazole compounds. The present invention further provides pharmaceutical compositions including an effective amount of the benzoxazole compounds for the prevention or treatment of malaria.
