122008-82-6Relevant academic research and scientific papers
Preparation method of herbicide cyhalofop-butyl
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Paragraph 0019-0053; 0055-0058, (2020/07/24)
The invention discloses a preparation method of herbicide cyhalofop-butyl, and particularly relates to the field of biological pharmacy, and the preparation method specifically comprises the followingsteps: 1, selecting a clean double-neck flask, adding an organic solvent into the double-neck flask, and dissolving (R)-2-[4-(2-fluoro-4-cyanophenoxy) phenoxy] propionic acid into the organic solvent; 2, continuously adding solid inorganic base into the double-neck flask, heating to 50 DEG C, keeping the temperature, and conducting the reaction for 0.5-1 hour in the double-neck flask. By dissolving (R)-2-[4-(2-fluoro-4-cyanophenoxy) phenoxy] propionic acid into an organic solvent, adding solid inorganic base, heating the reaction materials to reflux and carrying out the reaction with water, aHPLC tracking reaction is completed, so that the cyhalofop-butyl is shorter in reaction step, simple and convenient to operate, few in reaction by-products, easy to control, harmless and low in safety risk, the product yield and the optical purity are improved, part of raw materials in the reaction process can be recycled, the cost is low, and industrial production is facilitated.
Preparation method of cyhalofop-butyl
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, (2020/08/09)
The invention provides a preparation method of cyhalofop-butyl. The preparation method comprises the following steps of: (1) taking 3, 4-difluorobenzonitrile and (R)-2-(4-hydroxyphenoxy) propionic acid as raw materials, carrying out an etherification reaction in the presence of an acid-binding agent potassium carbonate and a water-carrying agent, and filtering to remove potassium fluoride, so as to obtain potassium salt as shown in a formula I: (2) acidifying the potassium salt as shown in the formula I, so as to obtain an acidified product; and (3) carrying out an esterification reaction on the acidification reaction product obtained in the step (2) and n-butyl alcohol to obtain cyhalofop-butyl. According to the preparation method, the problems that in the prior art, mixed salt cannot beseparated, many three wastes are generated, COD and ammonia nitrogen in wastewater are high, and the productivity cannot be improved are solved, resource utilization of by-products is achieved, the product yield is high, and continuous and large-scale production of cyhalofop-butyl is conveniently achieved.
Herbicide composition containing metamifop and quinclorac
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, (2019/03/08)
The invention discloses an herbicide composition containing metamifop and quinclorac. The herbicide composition comprises primary active ingredients and secondary active ingredients, wherein the primary active ingredients comprise the following components in parts by mass: 5-10 parts of metamifop and 10-20 parts of quinclorac; the secondary active ingredients are selected from the following components in parts by mass: 10-20 parts of cyhalofop-butyl, 3-8 parts of bispyribac-sodium, 1-6 parts of halosulfuron-methyl, 3-7 parts of pyrazosulfuron-ethyl and 6-10 parts of pyribenzoxim; and the secondary active ingredients refer to one of cyhalofop-butyl, bispyribac-sodium, halosulfuron-methyl, pyrazosulfuron-ethyl and pyribenzoxim. The invention relates to the technical field of herbicides. According to the herbicide composition containing metamifop and quinclorac disclosed by the invention, the problems such as herbicide resistant weed plants appearing, soil contamination, degradation of water, harm of non-weeds and the like are solved.
A method for synthesizing cyhalofop
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Paragraph 0012-0017, (2019/07/11)
The invention discloses a method for synthesizing cyhalofop-. In order to (R)- 2 - [4 - (4 - cyano - 2 - monofluoro-benzene oxygen radical) phenoxy] propionic acid methyl ester and butyl alcohol as the raw material, the function of the catalyst for produc
Synthesis method of cyhalofopbutyl raw pesticide
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Paragraph 0027; 0029; 0030; 0032; 0033; 0035; 0036-0039, (2019/05/08)
The invention relates to the field of organic synthesis, in particular to a synthesis method of cyhalofopbutyl raw pesticide. The method includes: firstly taking (R)-2-(4-hydroxphenoxyl)propionic acidand n-butyl alcohol as the raw materials to synthesize
Method for synthesizing cyhalofop-butyl
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, (2018/03/06)
The invention discloses a method for synthesizing cyhalofop-butyl. The method comprises the following steps: taking R-2-(4-hydroxyphenoxy) propionic acid and 3,4-dichlorobenzonitrile as raw materials;and carrying out salifying, etherification, neutralization, esterification, fluorination reaction and post treatment to obtain the cyhalofop-butyl. According to the synthetic method disclosed by theinvention, by taking 3,4-dichlorobenzonitrile as the raw material, the cost of the raw material is greatly reduced; a reaction rout is simple and acidchloride reaction is avoided, so that the requirement on equipment is reduced and simplicity and convenience in operation are realized; in addition, both a solvent and a catalyst can be recycled and reused; the discharge amount of three wastes is small, and reaction conditions are mild; and the method is favorably popularized to industrial production.
Method used for synthesis of cyhalofop butyl
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Paragraph 0043; 0044, (2018/03/01)
The invention discloses a method used for synthesis of cyhalofop butyl. According to the method, R-(+)-2-(4-hydroxyphenoxy) propanoic acid and 3, 4-difluorobenzonitrile are taken as raw materials, andsalt forming, etherification, esterification, water washing, and dehydration are carried out so as to obtain cyhalofop butyl. The synthetic method possesses following advantages: the reaction route is simple; a sodium hydroxide solution is taken as a raw material in the salt forming process, raw material cost is reduced greatly, no carbon dioxide gas is generated, and the safety is high; no acylating chlorination reaction is adopted, equipment requirement is reduced, operation is simplified, the solvent can be recycled, the environment compatibility is excellent, reaction conditions are mild,and the method is beneficial for popularization and large scale production.
Cyhalofop butyl synthetic method
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Paragraph 0020; 0021, (2017/10/26)
The invention relates to the field of chemical industry, and discloses a cyhalofop butyl synthetic method. The method comprises the following steps: 1) R-2-(4-hydroxyphenoxy)propionic acid and a catalyst are dissolved in an organic solvent to obtain a mixed solution M1; 2) slowly adding an acid binding agent in the solution M1 until no gas is generated to obtain a mixed solution M2; 3) adding bromobutane in the solution M2, reacting the materials to generate an intermediate R-2-(4-hydroxyphenoxy)butyl propionate at the temperature of 85-95 DEG C; and 4) keeping the temperature in the step 3), and adding 3,4-difluorobenzonitrile and reacting to generate the target product cyhalofop butyl. Compared with the prior art, a whole process is completed in a same reaction container, only steps (3) and (4) in the reaction keep the temperature at 85-95 DEG C, The subsequent raw materials can be directly added, the process is simple, the operation is easy, the reaction rate is high, the synthesis efficiency is high, and the yield is high.
NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING AMIDE COMPOUND
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, (2017/08/26)
An object of the present invention is to provide a compound having the controlling activity on a noxious arthropod, and a noxious arthropod controlling agent containing an amide compound of formula (I): wherein X represents a nitrogen atom or a CH group, p represents 0 or 1, A represents a tetrahydrofuranyl group or the like, R1, R2, R3, R4, R5, R6 and R7 represent a hydrogen atom or the like, n represents 1 or 2, Y represents an oxygen atom or the like, m represents any integer of 0 to 7, and Q represents a C1-8 chain hydrocarbon group optionally having a phenyl group or the like, has the excellent noxious arthropod controlling effect.
