71301-98-9

Basic information

• Product Name: Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate
• Synonyms: Ethyl(R)-(+)-2-(4-hydroxyphenoxy)propanoate;(R)-ethyl 2-(4-hydroxyphenoxy)propanoate;(R)-2-(4-Hydroxyphenoxy)propionic acid ethyl ester;(R)-2-(p-Hydroxyphenoxy)propionic acid ethyl ester
• CAS NO: 71301-98-9
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210
• Mol File: 71301-98-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 36-37℃
• Boiling Point: 327℃
• Flash Point: 124℃
• Appearance: /
• Density: 1.156
• Vapor Pressure: 0.000106mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: 2-8°C
• PKA: 10.09±0.15(Predicted)
• CAS DataBase Reference: Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate(71301-98-9)
• EPA Substance Registry System: Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate(71301-98-9)

Safety Data

• Hazardous Substances Data: 71301-98-9(Hazardous Substances Data)

Usage

General Description

Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate is a chemical compound with the molecular formula C12H14O4. It is a chiral ester, meaning it has a specific three-dimensional arrangement of atoms, and is commonly used as a building block in organic synthesis. Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate is often used in the production of pharmaceuticals, agrochemicals, and flavor and fragrance compounds. Its enantiomeric purity is important in many of these applications, as the specific arrangement of atoms determines its biological and chemical properties. Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate is also known by its trade name Ethyl 4-hydroxyphenylglycidate and is typically available as a colorless to pale yellow liquid with a fruity, floral odor.

InChI:InChI=1/C11H14O4/c1-3-14-11(13)8(2)15-10-6-4-9(12)5-7-10/h4-8,12H,3H2,1-2H3/t8-/m1/s1

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 66441-23-4 fenoxaprop-p-ethyl 
• 3731-52-0 3-Aminomethylpyridine 
• 3731-53-1 4-(aminomethyl)pyridine 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 765-30-0 Cyclopropylamine 
• 2516-47-4 cyclopropanemethylamine 
• 74497-15-7 (L) Ethyl 2-chloropropanoate 
• 123-31-9 hydroquinone 
• 131775-56-9 (R)-2-(p-acetylphenoxy)propionic acid ethyl ester 
• 65343-67-1 ethyl 2-(4-hydroxyphenoxy)propanoate 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 

Downstream Products

• 94050-90-5 (R)-2-(4-hydroxyphenoxy)propionic acid 
• 122008-78-0 cyhalofop-butyl 
• 113776-20-8 (-)-ethyl (2S)-2-[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]propanoate 
• 66441-23-4 fenoxaprop-p-ethyl 

Relevant articles and documents

Resolution of (R, S)-ethyl-2-(4-hydroxyphenoxy) propanoate using lyophilized mycelium of Aspergillus oryzae WZ007

The mycelium of Aspergillus oryzae WZ007 was successfully developed to kinetic resolution of (R, S)-ethyl-2-(4-hydroxyphenoxy) propanoate ((R, S)-EHPP) for production of (R)-ethyl-2-(4-hydroxyphenoxy) propanoate ((R)-EHPP). The key biocatalytic process parameters (pH, temperature, rotation speed and substrate concentration) were optimized. Under the optimum conditions, the optical purity of (R)-EHPP was improved up to >99% when the conversion was above 49%. A. oryzae WZ007 whole-cell lipase exhibited high reaction capacity, enantioselectivity and good reusability. The tolerable substrate concentration was 0.5 mol/L, and dry mycelium of A. oryzae WZ007 maintains over 80% of its initial activity after eight repeating cycles. Therefore the enzymatic preparation of (R)-EHPP route was suitable for industrial application.

A PROCESS FOR OPTICAL PURE (R)-2-PHENOXYPROPIONIC ACID DERIVATIVES

The present invention relates to a method for manufacturing optically active (R)-2-phenoxypropionic acid derivatives. More particularly, the present invention relates to a method for manufacturing optically active (R)-2-phenoxypropionic acid derivatives with high purity by using p-substituted phenol derivatives and alkyl (S)-2-arylsulfonyloxypropionate as starting materials and reacting them at 60 to 100 °C in the presence of an alkalimetal salt as a base and. a hydrocarbon solvent.