1220106-68-2Relevant academic research and scientific papers
Salicylaldehyde ester-induced chemoselective peptide ligations: Enabling generation of natural peptidic linkages at the serine/threonine sites
Li, Xuechen,Lam, Hiu Yung,Zhang, Yinfeng,Chan, Chun Kei
, p. 1724 - 1727 (2010)
A serine/threonine-based chemoselective ligation method is described. It uses an O-salicylaldehyde ester at the C-terminus, reacting with N-terminal serine or threonine to realize peptide ligations. The utility of the O-salicylaldehyde ester enables the rapid coupling reaction and the production of an N,O-benzylidene acetal intermediate, which is readily converted into natural peptidic linkages (Xaa-Ser/Thr) at the ligation site.
