122019-53-8

Usage

Uses

Used in Pharmaceutical Industry:
1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate is used as a key intermediate in the synthesis of various drugs and bioactive compounds for its unique structural features that can be leveraged to create novel therapeutic agents.
Used in Chemical Research:
1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate is utilized as a subject of chemical research and exploration due to its structural complexity, offering opportunities for the development of new synthetic pathways and understanding of its reactivity and potential applications in various chemical processes.

Upstream product

• 874-24-8 3-hydroxypyridine-2-carboxylic acid 
• 34619-03-9 tert-butyldicarbonate 
• 62733-99-7 methyl 3-hydroxypicolinate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 208649-02-9 (+/-)-cis-3-hydroxypiperidine-2-carboxylic acid 
• 220223-44-9 4-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-butyric acid methyl ester 

Downstream Products

• 220223-47-2 (2S,3S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(imidazole-1-carbothioyloxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 150779-99-0 (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperidine 
• 150779-88-7 (2S,3S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 150779-90-1 tert-butyl (R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)piperidine-1-carboxylate 
• 856015-17-3 (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-piperidine 
• 60343-64-8 (R)-(1-tosylpiperidin-2-yl)methanol 

Relevant academic research and scientific papers

AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory effect on PD-1 and PD-L1, and can effectively relieve or treat cancers and other related diseases.

β-Hydroxypiperidinecarboxylates: Additions to the chiral pool from bakers' yeast reductions of β-ketopiperidinecarboxylates

Reduction of the piperidine keto esters 16-19 using fermenting bakers' yeast provides high yields of the corresponding hydroxy esters 20, 26, 32 and 37 respectively, exclusively as the cis-diastereoisomers and with good levels (≥80%) of enantiomeric enrichment. The relative stereochemistries of the products were deduced from NMR data while the absolute configurations were determined by degradation to known piperidinemethanol derivatives or, in the case of hydroxy ester 37, by homologation to (R)-3-quinuclidinol 41b.

Evaluation and Synthesis of Aminohydroxyisoxazoles and Pyrazoles as Potential Glycine Agonists

Except for structurally similar small amino acids, such as alanine, β-alanine, and serine, compounds acting as glycine-receptor agonists are an unknown class of pharmacological agents.To investigate the potential of small, substituted heterocycles to act as glycine agonists, we have evaluated the similarities between glycine and a series of hydroxy- and amino-substituted pyrazoles and isoxazoles through complementary molecular modeling techniques.Using a "scorecard approach" to determine the overall similarity of projected agonist structures to glycine, we prioritized synthesis and subsequently prepared several novel derivatives.The biological activity of these compounds was compared to that of glycine by using a strychnine-mediated glycine receptor binding assay.Despite the close similarity in the calculated parameters when compared to glycine, no significant receptor-binding activity was observed for the targeted analogues.These results illustrate the structurally exacting nature of the glycine receptor.