122019-53-8

Basic information

• Product Name: 1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate
• Synonyms: 1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate;1,2-Piperidinedicarboxylic acid, 3-oxo-, 1-(1,1-diMethylethyl) 2-Methyl ester;3-Oxo-1,2-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester;1-(tert-butoxycarbonyl)-2-methyl-3-oxopiperidine-2-carboxylic acid;Methyl 1-Boc-3-oxopiperidine-2-carboxylate
• CAS NO: 122019-53-8
• Molecular Formula: C12H19NO5
• Molecular Weight: 257.28296
• Mol File: 122019-53-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate(122019-53-8)
• EPA Substance Registry System: 1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate(122019-53-8)

Safety Data

• Hazardous Substances Data: 122019-53-8(Hazardous Substances Data)

Usage

General Description

1-tert-Butyl 2-Methyl 3-oxopiperidine-1,2-dicarboxylate is a chemical compound with a complex structure. It is an ester, with a tert-butyl group attached to the nitrogen atom of a piperidine ring. The presence of a methyl group and a 3-oxo (ketone) group on the piperidine ring, combined with two carboxylate groups, gives this compound its unique properties. It has potential applications in the pharmaceutical industry, particularly in the synthesis of various drugs and bioactive compounds. Additionally, its structural complexity and unique features make it an interesting target for chemical research and exploration. However, due to its complexity and potential reactivity, careful handling and proper safety measures are necessary when working with this compound.

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 62733-99-7 methyl 3-hydroxypicolinate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 874-24-8 3-hydroxypyridine-2-carboxylic acid 
• 220223-44-9 4-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-butyric acid methyl ester 
• 208649-02-9 (+/-)-cis-3-hydroxypiperidine-2-carboxylic acid 

Downstream Products

• 220223-47-2 (2S,3S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(imidazole-1-carbothioyloxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 150779-99-0 (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperidine 
• 150779-88-7 (2S,3S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 150779-90-1 tert-butyl (R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)piperidine-1-carboxylate 
• 856015-17-3 (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-piperidine 
• 60343-64-8 (R)-(1-tosylpiperidin-2-yl)methanol 

Relevant articles and documents

AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory effect on PD-1 and PD-L1, and can effectively relieve or treat cancers and other related diseases.

Evaluation and Synthesis of Aminohydroxyisoxazoles and Pyrazoles as Potential Glycine Agonists

Except for structurally similar small amino acids, such as alanine, β-alanine, and serine, compounds acting as glycine-receptor agonists are an unknown class of pharmacological agents.To investigate the potential of small, substituted heterocycles to act as glycine agonists, we have evaluated the similarities between glycine and a series of hydroxy- and amino-substituted pyrazoles and isoxazoles through complementary molecular modeling techniques.Using a "scorecard approach" to determine the overall similarity of projected agonist structures to glycine, we prioritized synthesis and subsequently prepared several novel derivatives.The biological activity of these compounds was compared to that of glycine by using a strychnine-mediated glycine receptor binding assay.Despite the close similarity in the calculated parameters when compared to glycine, no significant receptor-binding activity was observed for the targeted analogues.These results illustrate the structurally exacting nature of the glycine receptor.